Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.
Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.
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DOI：
10.3390/ncrna7020036
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发表时间：
2021-06-17
期刊：
影响因子：
4.3
通讯作者：
Cerase A
中科院分区：
文献类型：
--
作者：
Aliperti V;Skonieczna J;Cerase A
发育是一个复杂的过程，受遗传、表观遗传和环境因素的影响。最近，长链非编码RNA（lncRNA）已成为包括大脑在内的几种组织中基因表达的关键调节因子。lncRNA的表达改变与几种神经退行性疾病、神经发育疾病和精神疾病有关。在神经发育和精神健康疾病中失调或突变的lncRNA的鉴定和表征对于理解脑功能中复杂的转录过程至关重要。至关重要的是，lncRNA可以作为治疗神经系统疾病的新靶点。在我们的综述中，我们首先总结了我们在细胞生物学背景下对lncRNA功能的理解的最新进展，然后讨论了它们与选定的神经元发育和神经系统疾病的关系。
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.
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