Prediction of individual brain maturity using fMRI.
Prediction of individual brain maturity using fMRI.
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DOI:
10.1126/science.1194144
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发表时间:
2010-09-10
期刊:
影响因子:
--
通讯作者:
Schlaggar BL
中科院分区:
文献类型:
--
作者:
Dosenbach NU;Nardos B;Cohen AL;Fair DA;Power JD;Church JA;Nelson SM;Wig GS;Vogel AC;Lessov-Schlaggar CN;Barnes KA;Dubis JW;Feczko E;Coalson RS;Pruett JR Jr;Barch DM;Petersen SE;Schlaggar BL
Group functional connectivity magnetic resonance imaging (fcMRI) studies have documented reliable changes in human functional brain maturity over development. Here we show that support vector machine-based multivariate pattern analysis extracts sufficient information from fcMRI data to make accurate predictions about individuals’ brain maturity across development. The use of only 5 minutes of resting-state fcMRI data from 238 scans of typically developing volunteers (ages 7 to 30 years) allowed prediction of individual brain maturity as a functional connectivity maturation index. The resultant functional maturation curve accounted for 55% of the sample variance and followed a nonlinear asymptotic growth curve shape. The greatest relative contribution to predicting individual brain maturity was made by the weakening of short-range functional connections between the adult brain’s major functional networks.
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