Seasonal Factors Are Associated with Activities of Enzymes Involved in High-Density Lipoprotein Metabolism among Pregnant Females in Ghana.
Seasonal Factors Are Associated with Activities of Enzymes Involved in High-Density Lipoprotein Metabolism among Pregnant Females in Ghana.
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DOI：
10.1016/j.cdnut.2023.102041
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发表时间：
2023-12
影响因子：
4.8
通讯作者：
Zivkovic, Angela M
中科院分区：
文献类型：
--
作者：
Hong, Brian V;Zheng, Jack Jingyuan;Romo, Eduardo Z;Agus, Joanne K;Tang, Xinyu;Arnold, Charles D;Adu-Afarwuah, Seth;Lartey, Anna;Okronipa, Harriet;Dewey, Kathryn G;Zivkovic, Angela M
在加纳进行的国际脂质营养补充剂（iLiNS）DYAD试验中，妊娠期和出生后少量脂质营养补充剂（SQ-LNS）可改善18月龄时补充母亲的儿童的高密度脂蛋白（HDL）胆固醇流出能力（CEC）和身长。然而，SQ-LNS对妊娠期间母体HDL功能的影响尚不清楚。这项横断面次要结局分析的目的是比较妊娠期间补充SQ-LNS与铁和叶酸（IFA）的母亲的HDL功能。在加纳的iLiNS-DYAD试验中，分析了来自妊娠36周女性子样本的存档血浆样本（N = 197）中的HDL CEC和3种HDL相关酶的活性。HDL功能和出生结果之间的相关性，炎症标志物C-反应蛋白（CRP）和α-1-酸性糖蛋白（AGP），和季节的影响进行了探讨，以确定这些因素对HDL功能的影响，在这个队列的孕妇。补充SQ-LNS的母亲与IFA对照组相比，HDL CEC、血浆卵磷脂胆固醇酰基转移酶（LCAT）活性、胆固醇酯转移蛋白（CETP）活性或磷脂转移蛋白（PLTP）活性无统计学显著差异，母体HDL功能与分娩结局之间无统计学显著关系。LCAT活性与血浆AGP（R =-0.19，P = 0.007）和CRP（R =-0.28，P = 0.001）呈负相关，CETP和LCAT活性在旱季高于雨季，PLTP活性在雨季高于旱季。在加纳的母亲补充SQ-LNS相比，IFA在怀孕期间没有可测量的差异，HDL功能和母亲HDL功能与分娩结果无关。然而，季节因素和炎症标志物与HDL功能相关，表明这些因素对HDL功能的影响比妊娠期间补充SQ-LNS更强。该研究注册为NCT 00970866。https://clinicaltrials.gov/study/NCT00970866
Small-quantity lipid-based nutrient supplements (SQ-LNS) during pregnancy and postnatally were previously shown to improve high-density lipoprotein (HDL) cholesterol efflux capacity (CEC) and length in the children of supplemented mothers at 18 mo of age in the International Lipid-Based Nutrient Supplements (iLiNS) DYAD trial in Ghana. However, the effects of SQ-LNS on maternal HDL functionality during pregnancy are unknown. The goal of this cross-sectional, secondary outcome analysis was to compare HDL function in mothers supplemented with SQ-LNS vs. iron and folic acid (IFA) during gestation. HDL CEC and the activities of 3 HDL-associated enzymes were analyzed in archived plasma samples (N = 197) from a subsample of females at 36 weeks of gestation enrolled in the iLiNS-DYAD trial in Ghana. Correlations between HDL function and birth outcomes, inflammatory markers C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP), and the effects of season were explored to determine the influence of these factors on HDL function in this cohort of pregnant females. There were no statistically significant differences in HDL CEC, plasma lecithin-cholesterol acyltransferase (LCAT) activity, cholesteryl ester transfer protein (CETP) activity, or phospholipid transfer protein (PLTP) activity between mothers supplemented with SQ-LNS compared with IFA control, and no statistically significant relationships between maternal HDL function and childbirth outcomes. LCAT activity was negatively correlated with plasma AGP (R = -0.19, P = 0.007) and CRP (R = -0.28, P < 0.001), CETP and LCAT activity were higher during the dry season compared to the wet season, and PLTP activity was higher in the wet season compared to the dry season. Mothers in Ghana supplemented with SQ-LNS compared with IFA during gestation did not have measurable differences in HDL functionality, and maternal HDL function was not associated with childbirth outcomes. However, seasonal factors and markers of inflammation were associated with HDL function, indicating that these factors had a stronger influence on HDL functionality than SQ-LNS supplementation during pregnancy. The study was registered as NCT00970866. https://clinicaltrials.gov/study/NCT00970866
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DOI：
10.4269/ajtmh.17-0620
发表时间：
2018-03
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Berry I;Walker P;Tagbor H;Bojang K;Coulibaly SO;Kayentao K;Williams J;Oduro A;Milligan P;Chandramohan D;Greenwood B;Cairns M
通讯作者：
Cairns M
影响因子：
4.6
作者：
Roland MCP;Godang K;Aukrust P;Henriksen T;Lekva T
通讯作者：
Lekva T
DOI：
10.1093/jn/nxz243
发表时间：
2020-02-01
期刊：
The Journal of nutrition
影响因子：
--
作者：
Adu-Afarwuah S;Young RR;Lartey A;Okronipa H;Ashorn P;Ashorn U;Oaks BM;Dewey KG
通讯作者：
Dewey KG
影响因子：
4.1
作者：
Hong BV;Zhu C;Wong M;Sacchi R;Rhodes CH;Kang JW;Arnold CD;Adu-Afarwuah S;Lartey A;Oaks BM;Lebrilla CB;Dewey KG;Zivkovic AM
通讯作者：
Zivkovic AM