Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants.
Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants.
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DOI：
10.1038/s41598-021-85777-3
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发表时间：
2021-03-18
影响因子：
4.6
通讯作者：
Lekva T
中科院分区：
文献类型：
--
作者：
Roland MCP;Godang K;Aukrust P;Henriksen T;Lekva T
胆固醇酯转运蛋白（CETP）调节高密度脂蛋白（HDL）-胆固醇（C），HDL-C对胎儿发育至关重要。我们假设，分娩大于胎龄（LGA）和小于胎龄（SGA）婴儿的妇女在脂蛋白、CETP活性和HDL-C的纵向变化方面存在差异，循环HDL-C较高或较低的妇女的胎盘显示出参与胆固醇/营养转运、胰岛素信号传导、炎症/细胞外基质（ECM）重塑的mRNA的差异表达。在妊娠期间测量循环脂质和CETP活性，在妊娠晚期测量NMR脂质组学，并研究与LGA和SGA婴儿的相关性。根据母体HDL-C水平的高低，对28例胎盘进行RNA测序。脂质组学显示，在分娩SGA婴儿的女性中，大VLDL中的甘油三酯和小HDL中的脂质/胆固醇/胆固醇酯较高。高HDL-C妇女的胎盘CETP表达水平降低，这与参与胆固醇/营养转运、胰岛素信号传导和炎症/ECM重塑的mRNA相关。胎盘和循环CETP水平与胎儿生长有关。在36-38周时低循环CETP活性与出生SGA婴儿相关。我们的研究结果表明母亲HDL-C水平升高，循环和胎盘中CETP水平降低与SGA婴儿之间存在联系。
Cholesteryl ester transfer protein (CETP) regulates high density lipoproteins (HDL)-cholesterol (C) and HDL-C is essential for fetal development. We hypothesized that women giving birth to large-for-gestational-age (LGA) and small-for-gestational age (SGA) infants differed in longitudinal changes in lipoproteins, CETP activity and HDL-C and that placentas from women with higher or lower circulating HDL-C displayed differential expression of mRNAs involved in cholesterol/nutrient transport, insulin signaling, inflammation/ extracellular matrix (ECM) remodeling. Circulating lipids and CETP activity was measured during pregnancy, NMR lipidomics in late pregnancy, and associations with LGA and SGA infants investigated. RNA sequencing was performed in 28 placentas according to higher and lower maternal HDL-C levels. Lipidomics revealed high triglycerides in large VLDL and lipids/cholesterol/cholesteryl esters in small HDL in women giving birth to SGA infants. Placentas from women with higher HDL-C had decreased levels of CETP expression which was associated with mRNAs involved in cholesterol/nutrient transport, insulin signaling and inflammation/ECM remodeling. Both placental and circulating CETP levels were associated with growth of the fetus. Low circulating CETP activity at 36–38 weeks was associated with giving birth to SGA infants. Our findings suggest a link between increased maternal HDL-C levels, low CETP levels both in circulation and placenta, and SGA infants.
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影响因子：
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作者：
IGLESIAS, A;MONTELONGO, A;LASUNCION, MA
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