Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children.
Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children.
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DOI：
10.1016/j.jaci.2009.07.024
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发表时间：
2009-11
影响因子：
14.2
通讯作者：
Lemanske, Robert F., Jr.
中科院分区：
文献类型：
--
作者：
Jackson, Daniel J.;Virnig, Christine M.;Gangnon, Ronald E.;Evans, Michael D.;Roberg, Kathy A.;Anderson, Elizabeth L.;Burton, Ryan M.;Salazar, Lisa P.;DaSilva, Douglas F.;Shanovich, Kathleen M.;Tisler, Christopher J.;Gern, James E.;Lemanske, Robert F., Jr.
关键词：
影响幼儿期呼出气一氧化氮（FeNO）分数的因素尚不完全清楚。研究FeNO与儿童过敏性致敏、总IgE、特应性皮炎、鼻炎、哮喘和肺功能（肺功能测定法）之间的关系。由于父母病史而有哮喘和其他过敏性疾病高风险的儿童在出生时就被招募并进行前瞻性随访。在6岁和8岁时通过在线技术测量FeNO。评价FeNO、各种特应性特征和哮喘之间的关系。在64%（135/210）的6岁儿童和93%（180/194）的8岁儿童中获得了可重复的FeNO测量结果。FeNO存在季节性变化。与未致敏儿童相比，6岁和8岁时吸入过敏原致敏儿童的FeNO水平升高[几何平均值（6岁，10.9 vs. 6.7 ppb，p<0.0001; 8岁，14.6 vs. 7.1 ppb，p<0.0001）]。在8岁时，哮喘儿童的FeNO高于无哮喘儿童，但6岁时则不高于无哮喘儿童（6岁，9.2 vs. 8.3 ppb，p = 0.48; 8岁，11.5 vs. 9.2 ppb，p = 0.03）。在8岁时，这种差异在包括空气过敏原致敏的多变量模型中不再显著（p=0.33）。在6岁或8岁时，FeNO和肺功能指数之间没有相关性。这些发现强调了当FeNO用作诊断和/或监测特应性疾病（特别是哮喘）的潜在生物标志物时，评估过敏原致敏状态的重要性。当FeNO用作诊断和/或监测特应性疾病（如哮喘）的生物标志物时，应仔细考虑是否存在过敏性致敏。这项儿科队列研究评估了FeNO与各种特应性特征之间的关系。结果表明，过敏性致敏应进行评估时，FeNO被用作生物标志物在临床或研究设置。
Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood. To examine the relationships between FeNO and allergic sensitization, total IgE, atopic dermatitis, rhinitis, asthma, and lung function (spirometry) in children. Children at high-risk of asthma and other allergic diseases due to parental history were enrolled at birth and followed prospectively. FeNO was measured by online technique at ages 6 and 8 years. Relationships among FeNO, various atopic characteristics, and asthma were evaluated. Reproducible FeNO measurements were obtained in 64% (135 of 210) of 6 year old and 93% (180 of 194) of 8 year old children. There was seasonal variability in FeNO. Children with aeroallergen sensitization at age 6 and 8 years had increased levels of FeNO compared to those not sensitized [geometric mean (6 years, 10.9 vs. 6.7 ppb, p<0.0001; 8 years, 14.6 vs. 7.1 ppb, p<0.0001)]. FeNO was higher in children with asthma than in those without asthma at 8 years, but not 6 years of age (6 years, 9.2 vs. 8.3 ppb, p = 0.48; 8 years, 11.5 vs. 9.2 ppb, p = 0.03). At 8 years of age, this difference was no longer significant in a multivariate model that included aeroallergen sensitization (p=0.33). There were no correlations between FeNO and spirometric indices at 6 or 8 years of age. These findings underscore the importance of evaluating allergen sensitization status when FeNO is used as a potential biomarker in the diagnosis and/or monitoring of atopic diseases, particularly asthma. When FeNO is utilized as a biomarker for the diagnosis and/or monitoring of atopic diseases such as asthma, the presence or absence of allergic sensitization should be carefully considered. This pediatric cohort study evaluates the relationships between FeNO and various atopic characteristics. The results suggest that allergic sensitization should be evaluated when FeNO is used as a biomarker in clinical or research settings.
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影响因子：
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