Serum Anti-Aging Protein α-Klotho Mediates the Association between Diet Quality and Kidney Function.
Serum Anti-Aging Protein α-Klotho Mediates the Association between Diet Quality and Kidney Function.
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作者：
Cai Q;Hu S;Qi C;Yin J;Xu S;Hou FF;Li A
坚持健康的饮食模式与降低肾功能障碍的风险有关。然而，饮食与肾功能之间关系的年龄相关机制仍不清楚。本研究旨在探讨血清 α-Klotho（一种抗衰老蛋白）在健康饮食和肾功能之间的中介作用。对 2007 年至 2016 年参加国家健康和营养检查调查 (NHANES) 的 12,817 名年龄在 40 岁至 79 岁之间的个体进行了一项横断面研究。对于每位参与者，计算了 2015 年健康饮食指数 (HEI-2015) 分数，作为健康饮食模式的衡量标准。基于肌酐的估计肾小球滤过率（eGFR）用于评估肾功能。在调整潜在混杂因素后，使用多变量回归模型分析标准化 HEI-2015 评分与 eGFR 之间的关联。进行因果中介分析以评估血清 α-Klotho 是否影响这种关联。所有个体的平均 eGFR 为 86.8 ± 19.8 mL/min 每 1.73 m2。高标准化 HEI-2015 评分与高 eGFR 相关（β [95% CI]，0.94 [0.64–1.23]；p < 0.001）。中介分析显示，在 NHANES 中，血清 α-Klotho 占标准化总体 HEI-2015 评分、总水果、整个水果、蔬菜和豆类以及全谷物与 eGFR 关联的 5.6-10.5%。根据亚组分析结果，血清α-Klotho在60-79岁参与者和男性中发挥中介作用。健康饮食可以通过上调血清抗衰老α-Klotho 来促进肾功能。这一新途径对饮食建议和肾脏健康具有重要意义。
Adherence to healthy dietary patterns is associated with a reduced risk of kidney dysfunction. Nevertheless, the age-related mechanisms that underpin the relationship between diet and kidney function remain undetermined. This study aimed to investigate the mediating role of serum α-Klotho, an anti-aging protein, in the link between a healthy diet and kidney function. A cross-sectional study was conducted on a cohort of 12,817 individuals aged between 40 and 79 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. For each participant, the Healthy Eating Index 2015 (HEI-2015) score was calculated as a measure of a healthy dietary pattern. Creatinine-based estimated glomerular filtration rate (eGFR) was used to assess kidney function. Multivariable regression models were used to analyze the association between the standardized HEI-2015 score and eGFR after adjusting for potential confounders. Causal mediation analysis was performed to assess whether serum α-Klotho influenced this association. The mean (±SD) eGFR of all individuals was 86.8 ± 19.8 mL/min per 1.73 m2. A high standardized HEI-2015 score was associated with a high eGFR (β [95% CI], 0.94 [0.64–1.23]; p < 0.001). The mediation analysis revealed that serum α-Klotho accounted for 5.6–10.5% of the association of standardized overall HEI-2015 score, total fruits, whole fruits, greens and beans, and whole grain with eGFR in the NHANES. According to the results from the subgroup analysis, serum α-Klotho exerted a mediating effect in the participants aged 60–79 years and in males. A healthy diet may promote kidney function by up-regulating serum anti-aging α-Klotho. This novel pathway suggests important implications for dietary recommendations and kidney health.
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影响因子：
4.8
作者：
Kirkpatrick SI;Reedy J;Krebs-Smith SM;Pannucci TE;Subar AF;Wilson MM;Lerman JL;Tooze JA
通讯作者：
Tooze JA
影响因子：
5.9
作者：
Millar SR;Navarro P;Harrington JM;Perry IJ;Phillips CM
通讯作者：
Phillips CM
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei
DOI：
10.1053/j.ajkd.2016.05.019
发表时间：
2016-12
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Rebholz CM;Crews DC;Grams ME;Steffen LM;Levey AS;Miller ER 3rd;Appel LJ;Coresh J
通讯作者：
Coresh J
影响因子：
7.1
作者：
Yin, Jiawei;Huang, Yue;Liu, Liegang
通讯作者：
Liu, Liegang