Dietary Quality Determined by the Healthy Eating Index-2015 and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis in Middle-to-Older Aged Adults.
Dietary Quality Determined by the Healthy Eating Index-2015 and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis in Middle-to-Older Aged Adults.
复制标题
由2015年健康饮食指数和慢性低度炎症生物标志物决定的饮食质量：一项中老年成年人的横断面分析。
DOI：
10.3390/nu13010222
复制
发表时间：
2021-01-14
期刊：
影响因子：
5.9
通讯作者：
Phillips CM
中科院分区：
文献类型：
--
作者：
Millar SR;Navarro P;Harrington JM;Perry IJ;Phillips CM
低度全身性炎症与一系列慢性疾病有关。饮食可以调节炎症，并代表一个有前途的治疗目标，以减少代谢功能障碍。到目前为止，还没有研究检查健康饮食指数-2015（HEI-2015）饮食评分与炎症生物标志物的相关性。因此，我们的目标是评估HEI-2015评分与1989名46-73岁男性和女性的横断面样本中的一系列炎症生物标志物之间的关系，以检验更好的饮食质量与更有利的炎症生物标志物循环水平相关的假设。测定促炎细胞因子、脂肪细胞因子、急性期反应蛋白、凝血因子和白色血细胞计数。相关性和线性回归分析用于测试HEI-2015饮食评分与生物标志物浓度的关系。HEI-2015确定的较高的饮食质量与较低的C反应蛋白（CRP）和白细胞介素6浓度、白色血细胞（WBC）计数及其成分相关，并根据性别和年龄进行了调整。与CRP浓度和WBC计数的相关性在完全校正的模型中持续存在。未发现与补体成分3、肿瘤坏死因子α、脂联素、瘦素、β-内酰胺酶或纤溶酶原激活物抑制剂-1水平相关。我们的数据表明，由HEI-2015评分确定的中老年人的饮食质量与心脏代谢健康相关的炎症生物标志物相关。
Low-grade systemic inflammation is associated with a range of chronic diseases. Diet may modulate inflammation and represents a promising therapeutic target to reduce metabolic dysfunction. To date, no study has examined Healthy Eating Index-2015 (HEI-2015) diet score associations with biomarkers of inflammation. Thus, our objective was to assess relationships between the HEI-2015 score and a range of inflammatory biomarkers in a cross-sectional sample of 1989 men and women aged 46–73 years, to test the hypothesis that better dietary quality would be associated with more favourable circulating levels of inflammatory biomarkers. Pro-inflammatory cytokines, adipocytokines, acute-phase response proteins, coagulation factors and white blood cell counts were determined. Correlation and linear regression analyses were used to test HEI-2015 diet score relationships with biomarker concentrations. Higher dietary quality as determined by the HEI-2015 was associated with lower c-reactive protein (CRP) and interleukin 6 concentrations, white blood cell (WBC) counts and its constituents, adjusting for sex and age. Associations with CRP concentrations and WBC counts persisted in the fully adjusted models. No associations with complement component 3, tumour necrosis factor alpha, adiponectin, leptin, resistin or plasminogen activator inhibitor-1 levels were identified. Our data suggest that dietary quality, determined by the HEI-2015 score, in middle-to-older aged adults is associated with inflammatory biomarkers related to cardiometabolic health.
登录
查看更多内容
影响因子：
5
作者：
JACOBS, DR;ANDERSON, JT;BLACKBURN, H
通讯作者：
BLACKBURN, H
DOI：
10.18632/aging.100531
发表时间：
2013-01
期刊：
Aging
影响因子：
--
作者：
Howcroft TK;Campisi J;Louis GB;Smith MT;Wise B;Wyss-Coray T;Augustine AD;McElhaney JE;Kohanski R;Sierra F
通讯作者：
Sierra F
影响因子：
4.7
作者：
Ford, ES;Mokdad, AH;Liu, S
通讯作者：
Liu, S
DOI：
10.2174/1871530314666140922153350
发表时间：
2014
期刊：
Endocrine, metabolic & immune disorders drug targets
影响因子：
--
作者：
Casas R;Sacanella E;Estruch R
通讯作者：
Estruch R
糖尿病的医疗标准 - 2012年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association