Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.
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Galectin-1结合碳水化合物的代谢抑制突出抗肿瘤免疫力。
DOI：
10.1038/jid.2011.335
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发表时间：
2012-02
影响因子：
6.5
通讯作者：
Dimitroff, Charles J.
中科院分区：
文献类型：
--
作者：
Cedeno-Laurent, Filiberto;Opperman, Matthew J.;Barthel, Steven R.;Hays, Danielle;Schatton, Tobias;Zhan, Qian;He, Xiaoying;Matta, Khushi L.;Supko, Jeffrey G.;Frank, Markus H.;Murphy, George F.;Dimitroff, Charles J.
Galectin-1 (Gal-1) has been shown to play a major role in tumor immune escape by inducing apoptosis of effector leukocytes and correlating with tumor aggressiveness and disease progression. Targeting the Gal-1 – Gal-1 ligand axis, thus, represents a promising cancer therapeutic approach. Here, to test the Gal-1-mediated tumor immune evasion hypothesis and demonstrate the importance of Gal-1-binding N-acetyllactosamines in controlling the fate and function of anti-tumor immune cells, we treated melanoma- or lymphoma-bearing mice with peracetylated 4-fluoro-glucosamine (4-F-GlcNAc), a metabolic inhibitor of N-acetyllactosamine biosynthesis, and analyzed tumor growth and immune profiles. We found that 4-F-GlcNAc spared Gal-1-mediated apoptosis of T and NK cells by decreasing their expression of Gal-1-binding determinants. 4-F-GlcNAc enhanced tumor lymphocytic infiltration and promoted elevations in tumor-specific cytotoxic T cells and IFN-γ levels, while lowering IL-10 production. Collectively, our data suggest that metabolic lowering of Gal-1-binding N-acetyllactosamines may attenuate tumor growth by boosting anti-tumor immune cell levels, representing a promising approach for cancer immunotherapy.
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影响因子：
6.5
作者：
Descheny, Leyla;Gainers, Madeliene E.;Dimitroff, Charles J.
通讯作者：
Dimitroff, Charles J.
DOI：
10.1073/pnas.0706017104
发表时间：
2007-08-07
影响因子：
11.1
作者：
Juszczynski, Przemyslaw;Ouyang, Jing;Shipp, Margaret A.
通讯作者：
Shipp, Margaret A.
影响因子：
4.4
作者：
Hirata, T;Furie, BC;Furie, B
通讯作者：
Furie, B
影响因子：
3.1
作者：
SHARMA, M;BERNACKI, RJ;KORYTNYK, W
通讯作者：
KORYTNYK, W
影响因子：
5.4
作者：
Motran, Claudia C.;Molinder, Karen M.;Liu, Scot D.;Poirier, Francoise;Miceli, M. Carrie
通讯作者：
Miceli, M. Carrie