Resolving morphogenesis into quantifiable cell behaviours.

Resolving morphogenesis into quantifiable cell behaviours.
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DOI:
10.1242/dev.199794
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发表时间:
2022-11-01
期刊:
Development (Cambridge, England)
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其他
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形态发生是非常多样的,但其系统的量化,以确定产生不同表型的物理机制是可能的,通过量化潜在的细胞行为。这些是有限的和可定义的:它们包括细胞增殖、细胞分裂方向、细胞重排、定向基质产生、细胞添加/减少和细胞大小/形状变化。虽然这些类别中可能存在微小的变化,但总的来说,它们涵盖了所有可能的形态发生行为。本文总结了这些过程,讨论了它们的测量,并强调了一些突出的例子。总结:这篇文章描述了细胞有限的行为库如何为定量形态发生表型提供基础。
Morphogenesis is extremely diverse, but its systematic quantification to determine the physical mechanisms that produce different phenotypes is possible by quantifying the underlying cell behaviours. These are limited and definable: they consist of cell proliferation, orientation of cell division, cell rearrangement, directional matrix production, cell addition/subtraction and cell size/shape change. Although minor variations in these categories are possible, in sum they capture all possible morphogenetic behaviours. This article summarises these processes, discusses their measurement, and highlights some salient examples. Summary: This Development at a Glance article describes how a cells’ limited repertoire of behaviours provide the basis for quantifying morphogenetic phenotypes.
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