Hepatic Unsaturated Fatty Acids Are Linked to Lower Degree of Fibrosis in Non-alcoholic Fatty Liver Disease.
Hepatic Unsaturated Fatty Acids Are Linked to Lower Degree of Fibrosis in Non-alcoholic Fatty Liver Disease.
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DOI：
10.3389/fmed.2021.814951
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发表时间：
2021
影响因子：
3.9
通讯作者：
Vessby J
中科院分区：
文献类型：
--
作者：
Fridén M;Rosqvist F;Ahlström H;Niessen HG;Schultheis C;Hockings P;Hulthe J;Gummesson A;Wanders A;Rorsman F;Risérus U;Vessby J
背景：非酒精性脂肪性肝病（NAFLD）早期患者的肝脏脂质组已得到相当充分的研究。然而，关于NAFLD的更渐进形式的研究，即，肝纤维化，有限。材料与方法：通过气相色谱法测定胆固醇酯（CE）、磷脂（PL）和三酰甘油（TAG）中的肝脏脂肪酸。使用多变量逻辑回归模型评估脂肪酸和活检证实的NAFLD纤维化（n = 60）之间的横截面关联。将纤维化阶段二分为非轻度（F0-1）或显著纤维化（F2-4）。模型根据体重指数（BMI）、年龄和含马铃薯糖蛋白样磷脂酶结构域蛋白3（PNPLA 3 rs738409）（I148 M）基因型进行调整。次要分析检查了主要分析的相关性是否可以在相应的血浆脂质组分中得到证实。结果如下：PL二十二烷酸（22：0）与前列腺癌的发生直接相关[OR（95%CI）：1.86（1.00，3.45）]而PL二十二碳六烯酸（22：6 n-3）[OR（95%CI）：0.45（0.23，0.89）]、TAG油酸（18：1 n-9）[OR（95% CI）：0.52（0.28，0.95）]和18：1 n-9和异油酸（18：1 n-7）（18：1）[OR（95%CI）：0.52（0.28，0.96）]与肝纤维化呈负相关。在血浆中，TAG 18：1 n-9 [OR（95% CI）：0.55（0.31，0.99）]、TAG 18：1 [OR（95% CI）：0.54（0.30，0.97）]和PL 22：0 [OR（95% CI）：0.46（0.25，0.86）]与肝纤维化呈负相关。结论：较高的TAG 18：1 n-9水平与肝脏和血浆中较低的纤维化有关，可能反映了脂肪酸代谢的改变。PL 22：6 n-3是否对肝纤维化具有保护作用，以及肝22：0的潜在不良影响，需要进行大规模研究。
Background: The hepatic lipidome of patients with early stages of non-alcoholic fatty liver disease (NAFLD) has been fairly well-explored. However, studies on more progressive forms of NAFLD, i.e., liver fibrosis, are limited. Materials and methods: Liver fatty acids were determined in cholesteryl esters (CE), phospholipids (PL), and triacylglycerols (TAG) by gas chromatography. Cross-sectional associations between fatty acids and biopsy-proven NAFLD fibrosis (n = 60) were assessed using multivariable logistic regression models. Stages of fibrosis were dichotomized into none-mild (F0–1) or significant fibrosis (F2–4). Models were adjusted for body-mass index (BMI), age and patatin-like phospholipase domain-containing protein 3 (PNPLA3 rs738409) (I148M) genotype. A secondary analysis examined whether associations from the primary analysis could be confirmed in the corresponding plasma lipid fractions. Results: PL behenic acid (22:0) was directly associated [OR (95% CI): 1.86 (1.00, 3.45)] whereas PL docosahexaenoic acid (22:6n-3) [OR (95% CI): 0.45 (0.23, 0.89)], TAG oleic acid (18:1n-9) [OR (95% CI): 0.52 (0.28, 0.95)] and 18:1n-9 and vaccenic acid (18:1n-7) (18:1) [OR (95% CI): 0.52 (0.28, 0.96)] were inversely associated with liver fibrosis. In plasma, TAG 18:1n-9 [OR (95% CI): 0.55 (0.31, 0.99)], TAG 18:1 [OR (95% CI): 0.54 (0.30, 0.97)] and PL 22:0 [OR (95% CI): 0.46 (0.25, 0.86)] were inversely associated with liver fibrosis. Conclusion: Higher TAG 18:1n-9 levels were linked to lower fibrosis in both liver and plasma, possibly reflecting an altered fatty acid metabolism. Whether PL 22:6n-3 has a protective role, together with a potentially adverse effect of hepatic 22:0, on liver fibrosis warrants large-scale studies.
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影响因子：
7.1
作者：
Bjermo, Helena;Iggman, David;Riserus, Ulf
通讯作者：
Riserus, Ulf
影响因子：
2.7
作者：
Li B;Zhang C;Zhan YT
通讯作者：
Zhan YT
影响因子：
11.1
作者：
Bergström G;Berglund G;Blomberg A;Brandberg J;Engström G;Engvall J;Eriksson M;de Faire U;Flinck A;Hansson MG;Hedblad B;Hjelmgren O;Janson C;Jernberg T;Johnsson Å;Johansson L;Lind L;Löfdahl CG;Melander O;Östgren CJ;Persson A;Persson M;Sandström A;Schmidt C;Söderberg S;Sundström J;Toren K;Waldenström A;Wedel H;Vikgren J;Fagerberg B;Rosengren A
通讯作者：
Rosengren A
影响因子：
16.6
作者：
Roumans, Kay H. M.;Lindeboom, Lucas;Schrauwen-Hinderling, Vera B.
通讯作者：
Schrauwen-Hinderling, Vera B.
影响因子：
25.7
作者：
Allard, Johane P.;Aghdassi, Elaheh;Heathcote, Jenny E.
通讯作者：
Heathcote, Jenny E.