Shedding Light on the Role of Neurotransmitters in the Microenvironment of Pancreatic Cancer.
Shedding Light on the Role of Neurotransmitters in the Microenvironment of Pancreatic Cancer.
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揭示神经递质在胰腺癌微环境中的作用
DOI：
10.3389/fcell.2021.688953
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发表时间：
2021
影响因子：
5.5
通讯作者：
Tu H
中科院分区：
文献类型：
--
作者：
Liang Y;Li H;Gan Y;Tu H
胰腺癌（PC）是一种高度致命的恶性肿瘤，5年生存率低于8%。PC的命运不仅由癌细胞的恶性行为决定，还由周围的肿瘤微环境（TME）决定，该微环境由各种细胞（癌细胞、免疫细胞、基质细胞、内皮细胞和神经元）和非细胞（细胞因子、神经递质和细胞外基质）组分组成。胰腺TME具有神经密度增加和神经递质微环境浓度改变的独特特征。由神经元和非神经元细胞产生的神经递质，通过与肿瘤细胞上相应的受体结合，激活胞内下游信号，直接调控PC细胞的生物学行为。另一方面，神经递质也可以与其他细胞成分（如TME中的免疫细胞）通信，以促进癌症生长。本文综述了神经递质在PC发生和发展中的多效性作用，并着重讨论了神经递质如何以自分泌或旁分泌方式影响TME中的先天性和适应性免疫反应的新机制。更好地了解TME中神经递质和免疫细胞之间的相互作用可能有助于开发治疗PC的新有效疗法。
Pancreatic cancer (PC) is a highly lethal malignancy with a 5-year survival rate of less than 8%. The fate of PC is determined not only by the malignant behavior of the cancer cells, but also by the surrounding tumor microenvironment (TME), consisting of various cellular (cancer cells, immune cells, stromal cells, endothelial cells, and neurons) and non-cellular (cytokines, neurotransmitters, and extracellular matrix) components. The pancreatic TME has the unique characteristic of exhibiting increased neural density and altered microenvironmental concentration of neurotransmitters. The neurotransmitters, produced by both neuron and non-neuronal cells, can directly regulate the biological behavior of PC cells via binding to their corresponding receptors on tumor cells and activating the intracellular downstream signals. On the other hand, the neurotransmitters can also communicate with other cellular components such as the immune cells in the TME to promote cancer growth. In this review, we will summarize the pleiotropic effects of neurotransmitters on the initiation and progression of PC, and particularly discuss the emerging mechanisms of how neurotransmitters influence the innate and adaptive immune responses in the TME in an autocrine or paracrine manner. A better understanding of the interplay between neurotransmitters and the immune cells in the TME might facilitate the development of new effective therapies for PC.
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DOI：
10.1177/0269881117725915
发表时间：
2017-09
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Carhart-Harris RL;Nutt DJ
通讯作者：
Nutt DJ
影响因子：
64.5
作者：
Binnewies, Mikhail;Mujal, Adriana M.;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
2.9
作者：
Bergquist, J;Josefsson, E;Ewing, A
通讯作者：
Ewing, A
DOI：
10.1073/pnas.0915139107
发表时间：
2010-02-09
影响因子：
11.1
作者：
Bhat, Roopa;Axtell, Robert;Steinman, Lawrence
通讯作者：
Steinman, Lawrence