Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children.
Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children.
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DOI：
10.1016/j.jaci.2012.12.666
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Miller RL
中科院分区：
文献类型：
--
作者：
Perzanowski MS;Chew GL;Divjan A;Jung KH;Ridder R;Tang D;Diaz D;Goldstein IF;Kinney PL;Rundle AG;Camann DE;Perera FP;Miller RL
对蟑螂的致敏是低收入城市社区哮喘发病率较高的最强风险因素之一;然而，与致敏发展相关的暴露时间尚未完全阐明。此外，暴露于燃烧副产物，包括多环芳烃（PAH），可能会增加过敏性致敏的发展。为了验证产前测量的国内蟑螂过敏原可以预测儿童早期蟑螂致敏性的假设，并且这种关联对于暴露于较高浓度的多环芳烃的儿童来说会更大。居住在纽约市的多米尼加和非洲裔美国孕妇入组。在妊娠晚期，孕妇佩戴个人空气采样器测量8种非挥发性多环芳烃和半挥发性多环芳烃芘，并从家中收集灰尘进行过敏原测量。检测儿童谷胱甘肽-S-转移酶mu（GSTM 1）基因多态性。在2岁、3岁、5岁和7岁的儿童中测量过敏原特异性IgE。产前厨房灰尘中的blag 2可预测5-7岁时蟑螂致敏[校正相对危险度（RR）1.15; P = 0.001; n = 349]。仅在高于[RR 1.22; P = 0.001]但不低于[RR 1.07; P = 0.24] 8个非挥发性PAH水平中位数总和的儿童中观察到相关性。在PAH较高且GSTM 1基因缺失的儿童中，这种关联最为明显[RR 1.54; P = 0.001]。出生前暴露于蟑螂过敏原与发生过敏性致敏的风险更大有关。暴露于非挥发性多环芳烃会增加这种风险，GSTM 1突变无效的儿童特别容易受到影响。家庭接触蟑螂过敏原测量产前预测致敏蟑螂在5-7岁。蟑螂过敏原预测致敏儿童也暴露于较高水平的空气中的非挥发性多环芳烃，这表明这些燃烧副产物可能作为佐剂在城市环境中的蟑螂致敏的发展。这些发现表明，针对过敏原或燃烧源进行一级预防可以成功地减少蟑螂致敏的发展。
Sensitization to cockroach is one of the strongest identified risk factors for greater asthma morbidity in low-income, urban communities; however, the timing of exposures relevant to development of sensitization has not been elucidated fully. Further, exposure to combustion byproducts, including polycyclic aromatic hydrocarbons (PAHs), may augment the development of allergic sensitization. To test the hypotheses that domestic cockroach allergen measured prenatally would predict cockroach sensitization in early childhood, and that this association would be greater for children exposed to higher concentrations of PAHs. Dominican and African-American pregnant women living in NYC were enrolled. In the third trimester, expectant mothers wore personal air samplers for measurement of 8 nonvolatile PAHs and the semi-volatile PAH pyrene, and dust was collected from homes for allergen measurement. Glutathione-s-transferase mu (GSTM1) gene polymorphisms were measured in children. Allergen-specific IgE was measured from the children at ages 2, 3, 5 and 7 years. Bla g2 in prenatal kitchen dust predicted cockroach sensitization at age 5–7 years [adjusted relative risk (RR) 1.15; P = 0.001; n = 349]. The association was observed only among children above [RR 1.22; P = 0.001], but not below [RR 1.07; P = 0.24] median sum of 8 nonvolatile PAH levels. The association was most pronounced among children with higher PAH and null in the GSTM1 gene [RR 1.54; P = 0.001]. Prenatal exposure to cockroach allergen was associated with a greater risk of developing allergic sensitization. This risk was increased by exposure to nonvolatile PAHs, with children null for the GSTM1 mutation particularly vulnerable. Domestic exposure to cockroach allergen measured prenatally predicted sensitization to cockroach at age 5–7 years. Cockroach allergen predicted sensitization only among children also exposed to higher levels of airborne non-volatile polycyclic aromatic hydrocarbons, indicating that these combustion byproducts may act as adjuvants in the development of cockroach sensitization in urban environments. These findings suggest that targeting either allergen or combustion sources with primary prevention could be successful in reducing the development of cockroach sensitization.
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纽约市儿童的家用空降黑碳和呼出的一氧化氮。
影响因子：
4.5
作者：
通讯作者：
--
影响因子：
10.4
作者：
Kass, Daniel;McKelvey, Wendy;Evans, David
通讯作者：
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影响因子：
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作者：
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Duschl, A
DOI：
10.1164/rccm.2112064
发表时间：
2002-08-15
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
10.4
作者：
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