Domestic airborne black carbon and exhaled nitric oxide in children in NYC.
Domestic airborne black carbon and exhaled nitric oxide in children in NYC.
复制标题
纽约市儿童的家用空降黑碳和呼出的一氧化氮。
DOI：
10.1038/jes.2012.3
复制
发表时间：
2012-05
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
不同的燃烧副产物和过敏原暴露可能在一定程度上解释了纽约市社区哮喘患病率(3%-18%)的显著差异。呼吸道炎症的亚临床变化可以用呼出的一氧化氮(FeNO)分数来衡量。FeNO可以用来测试这些环境暴露对呼吸道炎症的独立影响。来自哮喘患病率较低(3-9%，n=119)和较高(11-18%，n=121)社区的7岁和8岁儿童参加了一项哮喘病例对照研究。在家访期间，测量了FeNO，并收集了床尘(过敏原)和空气(黑碳)样本。对参与者住宅周围500米的社区建筑环境特征进行了评估。家庭空气中的黑碳浓度与社区哮喘患病率(P<；0.001)、卡车路线的社区密度(P<；0.001)和燃烧残油的建筑物(P<；0.001)相关。哮喘组FeNO浓度高于非喘息组(≥4次/年)(P=0.002)。在无血清过敏的儿童中，FeNO浓度与国产炭黑相关(P=0.012)，在有血清过敏的儿童中，FeNO浓度与尘螨变应原相关(P=0.020)。家庭空气中的黑碳与社区哮喘患病率和FeNO之间的关联表明，有必要对卡车排放标准和剩余石油使用进行进一步的公共卫生干预。
Differential exposure to combustion by-products and allergens may partially explain the marked disparity in asthma prevalence (3%–18%) among New York City neighborhoods. Subclinical changes in airway inflammation can be measured by fractional exhaled nitric oxide (FeNO). FeNO could be used to test independent effects of these environmental exposures on airway inflammation. Seven and eight year-old children from neighborhoods with lower (range 3–9%, n=119) and higher (range 11–18%, n=121) asthma prevalence participated in an asthma case-control study. During home visits, FeNO was measured, and samples of bed dust (allergens) and air (black carbon) were collected. Neighborhood built-environment characteristics were assessed for the 500m surrounding participants’ homes. Airborne black carbon concentrations in homes correlated with neighborhood asthma prevalence (P<0.001) and neighborhood densities of truck routes (P<0.001) and buildings burning residual oil (P<0.001). FeNO concentrations were higher among asthmatics with compared to asthmatics without frequent wheeze (≥4 times/year) (P=0.002). FeNO concentrations correlated with domestic black carbon among children without seroatopy (P=0.012) and with dust mite allergen among children with seroatopy (P=0.020). The association between airborne black carbon in homes and both neighborhood asthma prevalence and FeNO suggest that further public health interventions on truck emissions standards and residual oil use are warranted.
登录
查看更多内容
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
影响因子：
4.3
作者：
Bosson, Jenny;Pourazar, Jamshid;Blomberg, Anders
通讯作者：
Blomberg, Anders
影响因子：
10.4
作者：
Delfino, Ralph J;Staimer, Norbert;Gillen, Dan;Tjoa, Thomas;Sioutas, Constantinos;Fung, Kochy;George, Steven C;Kleinman, Michael T
通讯作者：
Kleinman, Michael T
DOI：
10.1164/ajrccm.159.1.9804063
发表时间：
1999-01-01
影响因子：
24.7
作者：
Baraldi, E;Carrà, S;Zacchello, F
通讯作者：
Zacchello, F
影响因子：
24.3
作者：
ASHER, MI;KEIL, U;WILLIAMS, HC
通讯作者：
WILLIAMS, HC