Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors.
Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors.
复制标题
用于实体瘤过继细胞治疗的间皮素靶向 CAR-T 细胞。
DOI：
10.5114/aoms.2019.84888
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Han SY
中科院分区：
文献类型：
--
作者：
Zhang GZ;Li TF;Han SY
CAR-T细胞的过继细胞治疗在癌症，特别是血液系统恶性肿瘤方面取得了重大进展。然而，实体瘤的治疗仍然面临着巨大的挑战，仍然是一个未满足的医疗需求。有几个因素导致不充分的反应：肿瘤异质性，T细胞向肿瘤组织的低效归巢，免疫抑制微环境和特异性抗原的缺乏。间皮素是一种在多种实体瘤中高度表达的细胞表面糖蛋白。因此，它作为肿瘤免疫治疗的分子靶点受到了广泛的关注。在这里，我们描述了实体肿瘤对CAR-T细胞施加的屏障，概述了间皮素作为免疫治疗靶点的基本原理，总结了间皮素靶向治疗的临床前和临床结果，并推断了针对间皮素的CAR-T细胞治疗实体肿瘤的预期结果。
Significant progresses have been made in adoptive cell therapy with CAR-T cells for cancers, especially for hematological malignancies. However, the treatment of solid tumors still poses a tremendous challenge and remains an unmet medical need. Several factors are held responsible for the inadequate responses: tumor heterogeneity, inefficient homing of T cells to tumor tissues, immunosuppressive microenvironment and the shortage of specific antigens shortage. Mesothelin is a cell-surface glycoprotein highly expressed in many types of solid tumors. As such, it has attracted much attention as a molecular target in cancer immunotherapy. Here, we delineate the barriers imposed by solid tumors on CARs, outline the rationale of mesothelin as a target for immunotherapy, summarize the preclinical and clinical results of mesothelin-targeted therapies, and extrapolate the expected results of CAR-T cells directed against mesothelin for solid tumors.
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