In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment.
In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment.
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DOI：
10.3390/ijms16059236
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发表时间：
2015-04-24
影响因子：
5.6
通讯作者：
Bei R
中科院分区：
文献类型：
--
作者：
Fantini M;Benvenuto M;Masuelli L;Frajese GV;Tresoldi I;Modesti A;Bei R
癌变是由基因改变触发的多步骤过程，基因改变激活不同的信号转导途径并导致正常细胞逐渐转变为癌细胞。多酚是植物中普遍表达的化合物，具有抗炎、抗菌、抗病毒、抗癌和免疫调节特性，所有这些都有益于人类健康。由于多酚能够通过直接相互作用或调节基因表达来调节参与致癌作用的多个靶标的活性，因此可以利用多酚来抑制癌细胞的生长。然而，与使用多酚作为抗癌剂相关的主要问题是其生物利用度差，这可能会阻碍单一化合物的体内作用。事实上，多酚类物质的吸收和生物分布较差，但在人体内代谢和排泄也较快。多酚的生物利用度差会影响递送至癌细胞的有效剂量。克服这一缺点的一种方法是使用不同的多酚或多酚和其他抗癌药物进行联合治疗，这比仅使用其中一种化合物的治疗更有效。本报告回顾了目前关于多酚或多酚与抗癌药物组合的抗癌作用的知识，重点是它们调节与癌症有关的多种信号转导途径的能力。
Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.
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影响因子：
11.5
作者：
Adhami, Vaqar Mustafa;Malik, Arshi;Mukhtar, Hasan
通讯作者：
Mukhtar, Hasan
影响因子：
2.9
作者：
Belen Granado-Serrano, Ana;Angeles Martin, Maria;Ramos, Sonia
通讯作者：
Ramos, Sonia
影响因子：
10.6
作者：
Bertram, John S.
通讯作者：
Bertram, John S.
影响因子：
3.1
作者：
Benvenuto, Monica;Fantini, Massimo;Bei, Roberto
通讯作者：
Bei, Roberto
DOI：
10.4161/cc.7.21.6969
发表时间：
2008-11-01
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Bin Hafeez B;Asim M;Siddiqui IA;Adhami VM;Murtaza I;Mukhtar H
通讯作者：
Mukhtar H