Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs study.
Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs study.
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DOI：
10.18332/tpc/173556
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发表时间：
2023
影响因子：
1.8
通讯作者：
Dai HD
中科院分区：
文献类型：
--
作者：
Kochvar A;Liu Y;Munafo M;Xu Z;Dai HD
电子尼古丁输送系统 (ENDS) 等含尼古丁产品 (NCP) 在青少年使用含尼古丁产品 (NCP) 的过程中越来越普遍，并且已经取代了传统的吸烟方式。本研究旨在探讨遗传和环境对美国儿童 ENDS 和其他 NCP 易感性和引发的影响。数据取自 2016 年至 2018 年基线青少年大脑与认知发展 (ABCD) 研究中的 886 对 9-10 岁同卵 (MZ) 和异卵 (DZ) 双胞胎。遗传力（h2）衡量归因于基因的总表型变异的比例。利用方差分量模型来分析共同环境 (c2) 和独特环境因素 (e2) 的影响，同时考虑双胞胎内的相关性。全国样本包括 50% 女性、69.5% 非西班牙裔白人、12.8% 非西班牙裔黑人和 11.6% 西班牙裔，平均年龄为 121.5 个月。两组分别为 60% DZ 和 40% MZ。 NCP 易感性的遗传力较低 (h2=0)，NCP 起始的遗传力中等 (h2=39%，p=0.02)。与 NCP 易感性相关的方差主要受到环境因素的影响，尤其是个人的独特因素（c2=37%，p<0.0001 vs e2=63%，p<0.0001）。相比之下，与 NCP 启动相关的方差分为常见和独特的环境因素（c2=32%，p=0.02 vs e2=29%，p=0.02）。在青少年使用电子尼古丁传送系统（ENDS）激增的时代，NCP的发生仍然是一种遗传特征，受到环境的共同影响。 NCP易感性很大程度上受环境因素，尤其是独特环境的影响。持续评估基因与环境的相互作用可以更好地为未来的青少年 NCP 干预提供信息。
Nicotine-containing products (NCPs) such as electronic nicotine delivery systems (ENDS) are increasingly common throughout the landscape of youth use of nicotine-containing products (NCP), and have overtaken traditional cigarette smoking modalities. This study seeks to examine the genetic and environmental influences on liability for susceptibility and initiation of ENDS and other NCPs among US children. Data were drawn from 886 monozygotic (MZ) and dizygotic (DZ) twin pairs aged 9–10 years in the Adolescent Brain & Cognitive Development (ABCD) study at the baseline during 2016–2018. Heritability (h2) measured the proportion of the total phenotypic variation attributable to genes. Variance component models were utilized to analyze influences from the common environment (c2) and unique environmental factors (e2), taking into account correlations within twin pairs. The national sample included 50% females, 69.5% of non-Hispanic Whites, 12.8% of non-Hispanic Blacks, and 11.6% of Hispanics, with a mean age of 121.5 months. The twin sets were 60% DZ and 40% MZ. Heritability was low for NCP susceptibility (h2=0) and moderate for NCP initiation (h2=39%, p=0.02). The variance associated with NCP susceptibility was primarily influenced by environmental factors, especially one’s unique factors (c2=37%, p<0.0001 vs e2=63%, p<0.0001). In contrast, the variance associated with NCP initiation was split across common and unique environmental factors (c2=32%, p=0.02 vs e2=29%, p=0.02). In the era with ENDS use surging among youth, NCP initiation remains to be a heritable trait with joint influence from the environment. NCP susceptibility is largely influenced by environmental factors, especially unique environments. Continued assessment of gene × environment interaction can better inform future youth NCP interventions.
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影响因子：
4.7
作者：
Iacono WG;Heath AC;Hewitt JK;Neale MC;Banich MT;Luciana MM;Madden PA;Barch DM;Bjork JM
通讯作者：
Bjork JM
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Chislovska, Natalia V.
DOI：
10.1093/jurban/jth151
发表时间：
2004-12-01
影响因子：
6.6
作者：
Echeverria, SE;Diez-Roux, AV;Link, BG
通讯作者：
Link, BG
影响因子：
5.5
作者：
Dai, Hongying Daisy;Ratnapradipa, Kendra;Sussman, Steve
通讯作者：
Sussman, Steve