Immunohistochemical examination of the distribution of macrophages and CGRP-immunoreactive nerve fibers in induced rat periapical lesions.
Immunohistochemical examination of the distribution of macrophages and CGRP-immunoreactive nerve fibers in induced rat periapical lesions.
复制标题
诱导大鼠根尖周病变中巨噬细胞和 CGRP 免疫反应性神经纤维分布的免疫组织化学检查。
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Maeda
中科院分区：
文献类型：
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作者：
Y. Toriya;I. Hashiguchi;K. Maeda
为了阐明降钙素基因相关肽（CGRP）在根尖周病变发生发展中的作用，我们采用免疫组织化学和定量方法检测了CGRP免疫反应性（IR）神经纤维和巨噬细胞的分布以及实验性诱导的大鼠根尖周病变骨组织的行为。虽然在暴露牙髓后7天没有观察到广泛的变化，但CGRP-IR神经纤维的数量增加到28天，此后减少。这些神经变化与巨噬细胞数量的变化密切相关，但在第7天巨噬细胞数量较对照组显著增加。当CGRP-IR神经纤维密度达到峰值时，组织修复开始发生，破骨细胞数量减少。这些结果提示巨噬细胞与CGRP-IR神经纤维之间可能存在密切的关系，CGRP-IR神经纤维可能参与了实验性大鼠根尖周围病变的组织修复。
To clarify the role of calcitonin gene-related peptide (CGRP) in the development of periapical lesions, we examined the distribution of CGRP-immunoreactive (IR) nerve fibers and macrophages, and the behavior of bone tissues in experimentally induced rat periapical lesions by immunohistochemical and quantitative methods. Although no extensive changes were observed at 7 days after pulp exposure, CGRP-IR nerve fibers increased in number until 28 days with a decrease thereafter. These neural changes were closely correlated with the alteration in number of macrophages except on day 7 when macrophages were significantly increased in number as compared with control rats. Tissue repair began to take place and a decrease in number of osteoclasts was observed when the density of CGRP-IR nerve fibers reached a peak. These results suggested that there might be a close relationship between macrophages and CGRP-IR nerve fibers and that CGRP-IR nerve fibers might participate in tissue repair in experimentally induced rat periapical lesions.
影响因子：
4.4
作者：
Y. Nong;R. Titus;J. Ribeiro;H. Remold
通讯作者：
Y. Nong;R. Titus;J. Ribeiro;H. Remold
影响因子：
4.2
作者：
KHAYAT, BG;BYERS, MR;KIMBERLY, CL
通讯作者：
KIMBERLY, CL