PI4P-Containing Vesicles from Golgi Contribute to Mitochondrial Division by Coordinating with Polymerized Actin.
PI4P-Containing Vesicles from Golgi Contribute to Mitochondrial Division by Coordinating with Polymerized Actin.
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DOI：
10.3390/ijms24076593
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发表时间：
2023-04-01
影响因子：
5.6
通讯作者：
Zhang, Yu-Hui
中科院分区：
文献类型：
--
作者：
Duan, Xinxin;Wei, Yunfei;Zhang, Meng;Zhang, Wenting;Huang, Yue;Zhang, Yu-Hui
关键词：
高尔基体衍生的含有PI4P的囊泡在线粒体分裂中起重要作用，这对于维持细胞内稳态是必不可少的。然而，含有PI4P的囊泡对线粒体分裂的影响的机制尚不清楚。在这里，我们发现，肌动蛋白似乎在含有PI4P的囊泡和线粒体之间的接触部位，引起线粒体分裂。增加来自高尔基体的PI4P的含量增加了肌动蛋白聚合并减少了线粒体的长度，这表明通过含有PI4P的囊泡的肌动蛋白聚合参与了PI4P囊泡相关的线粒体分裂。总的来说，我们的研究结果支持一个模型，其中来自高尔基体的含有PI4P的囊泡与肌动蛋白丝合作，通过促进肌动蛋白聚合来参与线粒体分裂，从而调节线粒体动力学。这项研究丰富了对调节线粒体分裂的途径的理解，并为线粒体动力学提供了新的见解。
Golgi-derived PI4P-containing vesicles play important roles in mitochondrial division, which is essential for maintaining cellular homeostasis. However, the mechanism of the PI4P-containing vesicle effect on mitochondrial division is unclear. Here, we found that actin appeared to polymerize at the contact site between PI4P-containing vesicles and mitochondria, causing mitochondrial division. Increasing the content of PI4P derived from the Golgi apparatus increased actin polymerization and reduced the length of the mitochondria, suggesting that actin polymerization through PI4P-containing vesicles is involved in PI4P vesicle-related mitochondrial division. Collectively, our results support a model in which PI4P-containing vesicles derived from the Golgi apparatus cooperate with actin filaments to participate in mitochondrial division by contributing to actin polymerization, which regulates mitochondrial dynamics. This study enriches the understanding of the pathways that regulate mitochondrial division and provides new insight into mitochondrial dynamics.
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影响因子：
64.8
作者：
Lee JE;Westrate LM;Wu H;Page C;Voeltz GK
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1407133111
发表时间：
2014-06-03
影响因子：
11.1
作者：
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