Cancer prevention through weight control-where are we in 2020?
Cancer prevention through weight control-where are we in 2020?
复制标题
DOI：
10.1038/s41416-020-01154-3
复制
发表时间：
2021-03
影响因子：
8.8
通讯作者：
UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
中科院分区：
文献类型：
--
作者：
Anderson AS;Renehan AG;Saxton JM;Bell J;Cade J;Cross AJ;King A;Riboli E;Sniehotta F;Treweek S;Martin RM;UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
来自流行病学研究的越来越多的数据强调了过多的体脂与癌症发病率之间的联系，但良好的指示性证据表明，有意减肥以及增加体力活动，作为一种降低癌症负担的经济有效的方法，前景广阔。然而，在我们对体脂或体力活动水平的变化如何与癌症有机械联系，以及它们对癌症风险的影响的程度的理解方面，仍然存在明显的差距。重要的是要调查成功实现短期适度减肥的计划与减肥维持和癌症发病率之间的因果关系。在试验设计中，还需要充分考虑体重减轻以及超重和肥胖持续时间对降低风险的长期影响。这些知识上的差距亟待解决，以加快未来癌症控制战略的制定和实施。试验设计的综合方法、孟德尔随机化研究和数据链接机会为解决当前的研究差距提供了真正的可能性。在这篇文章中，我们提出了为什么迫切需要非药物体重管理试验来支持癌症风险降低和帮助控制日益增长的全球癌症负担的案例。
Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.
登录
查看更多内容
DOI：
10.1136/bmj.k2234
发表时间：
2018-06-13
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Forouhi NG;Misra A;Mohan V;Taylor R;Yancy W
通讯作者：
Yancy W
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
8.8
作者：
Brenner H;Chen C
通讯作者：
Chen C
影响因子：
51.1
作者：
Higurashi, Takuma;Hosono, Kunihiro;Nakajima, Atsushi
通讯作者：
Nakajima, Atsushi
DOI：
10.1186/1479-5868-11-2
发表时间：
2014-01-15
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Aguiar EJ;Morgan PJ;Collins CE;Plotnikoff RC;Callister R
通讯作者：
Callister R