Pyrethroid resistance reduces the efficacy of space sprays for dengue control on the island of Martinique (Caribbean).
Pyrethroid resistance reduces the efficacy of space sprays for dengue control on the island of Martinique (Caribbean).
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DOI：
10.1371/journal.pntd.0001202
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发表时间：
2011-06
影响因子：
3.8
通讯作者：
Yébakima A
中科院分区：
文献类型：
--
作者：
Marcombe S;Darriet F;Tolosa M;Agnew P;Duchon S;Etienne M;Yp Tcha MM;Chandre F;Corbel V;Yébakima A
登革热正在马提尼克岛重新出现，对人类构成严重威胁。在登革热流行期间，使用拟除虫菊酯空间喷雾剂控制埃及伊蚊成虫，以迅速减少传播。不幸的是，随着拟除虫菊酯抗性Ae的出现，病媒控制方案面临着操作挑战。埃及人。为了评估拟除虫菊酯抗性对治疗效果的影响，在马提尼克岛的9个地方使用车载热雾器进行了溴氰菊酯和天然除虫菊酯的应用，其中Ae.埃及人对拟除虫菊酯有很强的抗药性。通过监测放置在哨兵笼中的自然抗性和实验室易感蚊子的死亡率来评估效力。在喷洒前、喷洒期间和喷洒后，估计幼虫和成虫的密度。结果表明，用溴氰菊酯处理的敏感哨兵蚊子的死亡率很高，而抗性蚊子的死亡率很低。无论是幼虫还是成虫，Ae都没有减少。处理后的埃及种群密度。这是首次有文件证明拟除虫菊酯耐药性妨碍使用拟除虫菊酯治疗方法控制登革热病媒。这些结果强调了登革热控制方案需要替代工具和策略。埃及伊蚊是登革热病毒在人群中的主要传播媒介，是世界范围内严重暴发的原因。在大多数国家，病媒控制是通过使用杀虫剂来减少蚊子数量。在流行病期间，拟除虫菊酯类杀虫剂（阻断神经鞘中的电压门控钠通道蛋白）通过车载热雾器进行空间喷洒来杀死成蚊。不幸的是，一些人口的Ae。埃及人对这些杀虫剂产生了抗药性，给公共卫生服务带来了业务挑战。在马提尼克岛（法属西印度群岛），1990年代发现了对拟除虫菊酯的抗药性。本研究评估了这种抗性对马提尼克岛9个地区病媒控制行动效力的影响。在这里，我们表明耐药性强烈降低了基于拟除虫菊酯的治疗方法的功效，从而强调迫切需要替代杀虫剂或工具来减少登革热传播。
Dengue fever is reemerging on the island of Martinique and is a serious threat for the human population. During dengue epidemics, adult Aedes aegypti control with pyrethroid space sprays is implemented in order to rapidly reduce transmission. Unfortunately, vector control programs are facing operational challenges with the emergence of pyrethroid resistant Ae. aegypti populations. To assess the impact of pyrethroid resistance on the efficacy of treatments, applications of deltamethrin and natural pyrethrins were performed with vehicle-mounted thermal foggers in 9 localities of Martinique, where Ae. aegypti populations are strongly resistant to pyrethroids. Efficacy was assessed by monitoring mortality rates of naturally resistant and laboratory susceptible mosquitoes placed in sentinel cages. Before, during and after spraying, larval and adult densities were estimated. Results showed high mortality rates of susceptible sentinel mosquitoes treated with deltamethrin while resistant mosquitoes exhibited very low mortality. There was no reduction of either larval or adult Ae. aegypti population densities after treatments. This is the first documented evidence that pyrethroid resistance impedes dengue vector control using pyrethroid-based treatments. These results emphasize the need for alternative tools and strategies for dengue control programs. The mosquito Aedes aegypti is the major vector of the Dengue virus in human populations and is responsible of serious outbreaks worldwide. In most countries, vector control is implemented by the use of insecticides to reduce mosquito populations. During epidemics, insecticides of the pyrethroid family (blocking the voltage gated sodium channel protein in the nerve sheath) are used by space spraying with vehicle mounted thermal foggers to kill adult mosquitoes. Unfortunately some populations of Ae. aegypti have become resistant to these insecticides, leading to operational challenges for public health services. In Martinique (French West Indies), resistance to pyrethroids was detected in the 1990s. The present study assessed the impact of this resistance on the efficacy of vector control operations in 9 localities of Martinique. Here we showed that the resistance strongly reduces the efficacy of pyrethroid-based treatments, thus emphasizing the urgent need for alternative insecticides or tools to reduce dengue transmission.
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DOI：
10.1590/s0074-02762006000300017
发表时间：
2006-05-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Maciel-de-Freitas, Rafael;Eiras, Álvaro Eduardo;Lourenço-de-Oliveira, Ricardo
通讯作者：
Lourenço-de-Oliveira, Ricardo
影响因子：
2
作者：
Lucia, Alejandro;Harburguer, Laura;Masuh, Hector
通讯作者：
Masuh, Hector
DOI：
10.1016/j.cimid.2004.03.013
发表时间：
2004-09-01
影响因子：
2
作者：
Gubler, DJ
通讯作者：
Gubler, DJ
影响因子：
3.8
作者：
Strode, Clare;Wondji, Charles S.;Ranson, Hilary
通讯作者：
Ranson, Hilary
影响因子：
1.9
作者：
Chung, YK;Lam-Phua, SG;Yatiman, R
通讯作者：
Yatiman, R