Deaf genetic testing and psychological well-being in deaf adults.
Deaf genetic testing and psychological well-being in deaf adults.
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聋哑成年人的聋哑基因检测和心理健康。
DOI：
10.1007/s10897-013-9573-7
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发表时间：
2013-08
影响因子：
1.9
通讯作者：
Sinsheimer, Janet S.
中科院分区：
文献类型：
--
作者：
Palmer, Christina G. S.;Boudreault, Patrick;Baldwin, Erin E.;Fox, Michelle;Deignan, Joshua L.;Kobayashi, Yoko;Sininger, Yvonne;Grody, Wayne;Sinsheimer, Janet S.
关键词：
有限的数据表明，从与非医学特征相关的遗传信息中增强自我认识可以对心理健康产生积极影响。聋人对聋人基因进行基因测试，以增加自知之明。因为耳聋被许多人认为是一种非医学特征，我们假设，得到为什么他们是聋人的基因解释的聋人会经历更多的心理健康。我们报告了一项前瞻性的纵向研究的结果，以确定基因测试(GJB2，Cx26；GJB6，Cx30)对聋人(N=209)在测试前遗传咨询以及测试结果披露后1个月和6个月后评估的感知个人控制力(PPC)、焦虑和抑郁的影响。受试者分为Cx阳性(n=82)和Cx阴性/不确定(n=127)。Cx组在PPC和焦虑随时间的变化上存在显著差异(PPC：Cx组*时间交互作用p=0.0007；焦虑：Cx组*时间交互p=0.002)，在测试结果公布后，Cx阳性组的PPC得分显著高于Cx阳性组，而焦虑得分显著低于阴性/不确定组。与测试前相比，Cx阳性组的PPC分数在1个月时增加(p=0.07)，焦虑分数在6个月时降低(p=0.03)。相反，在测试结果公布后1个月和6个月，CX阴性/不确定组的PPC分数下降(p=0.009，p<；0.0001)，而焦虑分数增加(p=0.09，p=0.02)。聋人基因检测影响聋人的心理健康。增加聋人接受基因测试的机会可能会潜在地增强自我认识，并增加那些接受基因解释的人的心理健康，这可能会给下游的健康带来好处。
Limited data suggest that enhanced self-knowledge from genetic information related to non-medical traits can have a positive impact on psychological well-being. Deaf individuals undertake genetic testing for deaf genes to increase self-knowledge. Because deafness is considered a non-medical trait by many individuals, we hypothesized that deaf individuals receiving a genetic explanation for why they are deaf will experience increased psychological well-being. We report results from a prospective, longitudinal study to determine the impact of genetic testing (GJB2, Cx26; GJB6, Cx30) on perceived personal control (PPC), anxiety, and depression in deaf adults (N=209) assessed following pre-test genetic counseling as well as 1-month and 6-months following test result disclosure. Participants were classified as Cx positive (n=82) or Cx negative/inconclusive (n=127). There was significant evidence for Cx group differences in PPC and anxiety over time (PPC: Cx group*time interaction p=0.0007; anxiety: Cx group*time interaction p=0.002), where PPC scores were significantly higher, and anxiety scores were significantly lower for the Cx positive group relative to the negative/inconclusive group following test result disclosure. Compared to pre-test, PPC scores increased at 1-month (p=0.07) and anxiety scores decreased at 6-months for the Cx positive group (p=0.03). In contrast, PPC scores decreased (p=0.009, p<0.0001) and anxiety scores increased (p=0.09, p=0.02) for the Cx negative/inconclusive group at 1- and 6-months post test result disclosure. Genetic testing for deaf genes affects the psychological well-being of deaf individuals. Increasing deaf adults’ access to genetic testing may potentially enhance self-knowledge and increase psychological well-being for those who receive a genetic explanation, which could offer downstream health benefits.
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影响因子：
1.9
作者：
Enns, Emily E.;Boudreault, Patrick;Palmer, Christina G. S.
通讯作者：
Palmer, Christina G. S.
影响因子：
2
作者：
Boudreault, Patrick;Baldwin, Erin E.;Palmer, Christina G. S.
通讯作者：
Palmer, Christina G. S.
影响因子：
3.5
作者：
Esplen, M. J.;Madlensky, L.;McLaughlln, J.
通讯作者：
McLaughlln, J.
DOI：
10.1002/ajmg.1320440315
发表时间：
1992-10-01
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
ARNOS, KS;CUNNINGHAM, M;MARAZITA, ML
通讯作者：
MARAZITA, ML
DOI：
10.1111/j.1749-6632.1991.tb19620.x
发表时间：
1991-09-30
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
ARNOS, KS;ISRAEL, J;CUNNINGHAM, M
通讯作者：
CUNNINGHAM, M