Nanoscale interfaces to biology.

Nanoscale interfaces to biology.
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DOI:
10.1016/j.cbpa.2010.06.186
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发表时间:
2010-10
影响因子:
7.8
通讯作者:
Hamad-Schifferli K
Hamad-Schifferli K
中科院分区:
生物学2区
文献类型:
--
作者:
Park S;Hamad-Schifferli K

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纳米技术在给生物学带来革命性变革方面有着巨大的希望。纳米材料的生物行为主要取决于它们与生物分子及其周围环境的接口方式。不幸的是,非特异性吸附等界面问题仍然是纳米生物技术和纳米医学成功的最大障碍,并阻碍了纳米技术在生物学中的广泛实际应用。不仅需要了解和控制纳米粒子的生物界面,而且必须将纳米粒子视为生物实体,而不是无机实体。此外,人们可以从工程的角度看待纳米颗粒-生物界面,意识到它具有独特的、可开发的特性。
Nanotechnology has held great promise for revolutionizing biology. The biological behavior of nanomaterials depends primarily on how they interface to biomolecules and their surroundings. Unfortunately, interface issues like non-specific adsorption are still the biggest obstacles to the success of nanobiotechnology and nanomedicine, and have held back widespread practical use of nanotechnology in biology. Not only does the biological interface of nanoparticles needs to be understood and controlled, but nanoparticles must be treated as biological entities rather than inorganic ones. Furthermore, one can adopt an engineering perspective of the nanoparticle-biological interface, realizing that it has unique, exploitable properties.
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