Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children's Study.
Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children's Study.
复制标题
日本环境与儿童研究中慢性炎症的母体血细胞计数参数及其与早产风险的关系
DOI：
10.1038/s41598-021-93101-2
复制
发表时间：
2021-07-30
影响因子：
4.6
通讯作者：
Japan Environment and Children’s Study Group
中科院分区：
文献类型：
--
作者：
Morisaki N;Piedvache A;Nagata C;Michikawa T;Morokuma S;Kato K;Sanefuji M;Shibata E;Tsuji M;Shimono M;Ohga S;Kusuhara K;Japan Environment and Children’s Study Group
中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）和淋巴细胞与单核细胞比率（LMR）是三种据报道反映亚临床慢性炎症负荷的预测性生物标志物。然而，这些生物标志物在怀孕期间如何变化及其在孕妇中的临床效用很少被研究。在日本环境与儿童研究中纳入的76，853例妊娠28-41周的单胎妊娠中，我们使用样条曲线观察了从第0周至第36周的母亲NLR、PLR和LMR值的分布，以及它们对有和无妊娠期高血压疾病的早产的预测值，在8-11周、12-17周和18-21周时测量胎盘萎缩和宫内生长受限（由于其共同的病理学和病理生理学特征，统称为缺血性胎盘疾病）。NLR和PLR随孕龄增加而增加，而LMR随孕龄增加而减少。在18-21周时观察到的高LMR和低NLR与IPD早产风险较高相关，但在早期妊娠时未观察到（比值比为1.80 [95% CI 1.02，3.19]/log[LMR];比值比为0.49 [95% CI 0.29，0.82]/log[NLR]）。所有参数均不能预测无IPD的早产。我们提供了一个强大的参考曲线，母亲的血细胞计数参数NLR，PLR和LMR孕周。
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), are three reportedly predictive biomarkers that reflect subclinical chronic inflammatory burden. However, how these biomarkers change during pregnancy and its clinical utility among pregnant women have been rarely studied. Among 76,853 singleton pregnancies delivered at 28–41 weeks of gestation that were enrolled in the Japan Environment and Children’s Study, we observed the distribution of maternal NLR, PLR, and LMR values from week 0 to week 36 using spline curves, as well as their predictive values for preterm delivery with and without hypertensive disorders in pregnancy, placental abruption and intrauterine growth restriction (collectively termed ischemic placental disease due to their shared pathological and pathophysiological features) for measurements at 8–11 weeks, 12–17 weeks, and 18–21 weeks. NLR and PLR increased, whereas LMR decreased, with increasing gestation. High LMR and low NLR observed at 18–21 weeks, but not at earlier gestations, were associated with higher risk of preterm delivery with IPD (odds ratio 1.80 [95% CI 1.02, 3.19] per log[LMR]; odds ratio 0.49 [95% CI 0.29, 0.82] per log[NLR]). All parameters were not predictive of preterm delivery without IPD. We provide a robust reference curve for maternal blood count parameters NLR, PLR, and LMR by gestational week.
登录
查看更多内容
DOI：
10.1126/science.1251816
发表时间：
2014-08-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Romero R;Dey SK;Fisher SJ
通讯作者：
Fisher SJ
影响因子：
7.2
作者：
Wei, Shu-Qin;Fraser, William;Luo, Zhong-Cheng
通讯作者：
Luo, Zhong-Cheng
DOI：
10.1080/14767058.2016.1237497
发表时间：
2017-01-01
影响因子：
1.8
作者：
Akgun, Nilufer;Kalem, Muberra Namli;Aktas, Hatice
通讯作者：
Aktas, Hatice
影响因子：
3.3
作者：
Balta, Sevket;Ozturk, Cengiz
通讯作者：
Ozturk, Cengiz
DOI：
10.4149/bll_2018_023
发表时间：
2018-01-01
影响因子：
1.5
作者：
Gumus, F.;Solak, I;Eryilmaz, M. A.
通讯作者：
Eryilmaz, M. A.