Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China.
Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China.
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雪貂獾狂犬病的起源及其作为中国东南部狂犬病潜在传播源的重要性
DOI：
10.1186/1471-2334-10-234
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发表时间：
2010-08-06
影响因子：
3.7
通讯作者：
Hu R
中科院分区：
文献类型：
--
作者：
Liu Y;Zhang S;Wu X;Zhao J;Hou Y;Zhang F;Velasco-Villa A;Rupprecht CE;Hu R
背景中国东南部地区频繁发生与雪貂相关的人类狂犬病病例，突显了缺乏以实验室为基础的监测，并敦促重新审视这种动物在狂犬病传播中的潜在重要性。为确定该地区人、狗狂犬病病例是否真的与雪貂有关，以及该地区与狂犬病相关的狂犬病的可能来源，进行了一次积极的狂犬病调查，以确定犬和雪貂狂犬病的感染频率和血清阳性率。方法对浙江省、江西省和安徽省中国东南部的狂犬病疫情进行回顾性调查。用荧光抗体试验对雪貂、獾和狗的脑组织进行了检测。狂犬病病毒分离并测序，用于系统发育分析。用狂犬病病毒中和抗体(VNA)对雪貂和狗的血清进行滴定。结果在采集的样本中，雪獾的狂犬病血清阳转率高于疫区的犬，最高可达95%。9种与雪貂獾相关的狂犬病病毒被分离、测序，并在系统发育上聚为一个单独的组。与同一狂犬病流行区犬分离株的核苷酸同源性为99.4%~99.8%，核蛋白和糖蛋白基因的同源性为83%~89%。结论在中国东南部地区长期狂犬病流行过程中，可能形成了一种独立的犬源性狂犬病。目前尚不清楚FB狂犬病在公共卫生中的最终作用。然而，治理雪貂獾咬伤，提高相关地区对狂犬病的认识和控制应是当务之急。
BackgroundThe frequent occurrence of ferret badger-associated human rabies cases in southeast China highlights the lack of laboratory-based surveillance and urges revisiting the potential importance of this animal in rabies transmission. To determine if the ferret badgers actually contribute to human and dog rabies cases, and the possible origin of the ferret badger-associated rabies in the region, an active rabies survey was conducted to determine the frequency of rabies infection and seroprevalence in dogs and ferret badgers.MethodsA retrospective survey on rabies epidemics was performed in Zhejiang, Jiangxi and Anhui provinces in southeast China. The brain tissues from ferret badgers and dogs were assayed by fluorescent antibody test. Rabies virus was isolated and sequenced for phylogenetic analysis. The sera from ferret badgers and dogs were titrated using rabies virus neutralizing antibodies (VNA) test.ResultsThe ferret badgers presented a higher percentage of rabies seroconversion than dogs did in the endemic region, reaching a maximum of 95% in the collected samples. Nine ferret badger-associated rabies viruses were isolated, sequenced, and were phylogenetically clustered as a separate group. Nucleotide sequence revealed 99.4-99.8% homology within the ferret badger isolates, and 83-89% homology to the dog isolates in the nucleoprotein and glycoprotein genes in the same rabies endemic regions.ConclusionsOur data suggest ferret badger-associated rabies has likely formed as an independent enzootic originating from dogs during the long-term rabies infestation in southeast China. The eventual role of FB rabies in public health remains unclear. However, management of ferret badger bites, rabies awareness and control in the related regions should be an immediate need.
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影响因子：
9.4
作者：
BOURHY, H;ROLLIN, PE;SUREAU, P
通讯作者：
SUREAU, P
影响因子：
11.8
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Zhang S;Tang Q;Wu X;Liu Y;Zhang F;Rupprecht CE;Hu R
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通讯作者：
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1.7
作者：
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