Control of stem cell fate and function by engineering physical microenvironments.
Control of stem cell fate and function by engineering physical microenvironments.
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DOI：
10.1039/c2ib20080e
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Kim DH
中科院分区：
文献类型：
--
作者：
Kshitiz;Park J;Kim P;Helen W;Engler AJ;Levchenko A;Kim DH
干细胞的表型表达和功能受其对可变微环境信号的综合反应调控，包括生长因子和细胞因子、基质介导的信号和细胞间相互作用。近年来，越来越多的证据表明，基质介导的信号包括应变、剪切应力、底物刚性和地形等机械刺激，这些刺激对干细胞表型的影响比以前认识到的更深远，例如通过控制基因转录和信号通路进行自我更新和分化。利用微纳米技术实现的多种细胞培养模型，我们开始系统和定量地研究细胞对相关机械生物学刺激组合的综合反应。本文综述了干细胞机械生物学工程物理刺激的最新进展，并讨论了如何利用微纳米工程平台来控制干细胞生态位环境，调节干细胞的命运和功能。
The phenotypic expression and function of stem cells are regulated by their integrated response to variable microenvironmental cues, including growth factors and cytokines, matrix-mediated signals, and cell-cell interactions. Recently, growing evidence suggests that matrix-mediated signals include mechanical stimuli such as strain, shear stress, substrate rigidity and topography, and these stimuli have a more profound impact on stem cell phenotypes than had previously been recognized, e.g. self-renewal and differentiation through the control of gene transcription and signaling pathways. Using a variety of cell culture models enabled by micro and nanoscale technologies, we are beginning to systematically and quantitatively investigate the integrated response of cells to combinations of relevant mechanobiological stimuli. This paper reviews recent advances in engineering physical stimuli for stem cell mechanobiology and discusses how micro- and nanoscale engineered platforms can be used to control stem cell niches environment and regulate stem cell fate and function.
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影响因子：
56.9
作者：
Cukierman, E;Pankov, R;Yamada, KM
通讯作者：
Yamada, KM
影响因子：
4
作者：
dela Paz, Nathaniel G.;Walshe, Tony E.;D'Amore, Patricia A.
通讯作者：
D'Amore, Patricia A.
DOI：
10.1083/jcb.200405004
发表时间：
2004-09-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Engler AJ;Griffin MA;Sen S;Bönnemann CG;Sweeney HL;Discher DE
通讯作者：
Discher DE
DOI：
10.1126/science.1171643
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Discher DE;Mooney DJ;Zandstra PW
通讯作者：
Zandstra PW
影响因子：
3.4
作者：
Gillies, Allison R.;Lieber, Richard L.
通讯作者：
Lieber, Richard L.