Therapeutic Vaccines for Tuberculosis: An Overview.
Therapeutic Vaccines for Tuberculosis: An Overview.
复制标题
DOI：
10.3389/fimmu.2022.878471
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
由结核分枝杆菌引起的结核病（TB）是世界上最致命的细菌感染，每年导致超过140万人死亡。一线抗生素治疗出现耐药性对成功治疗构成威胁，需要新的治疗选择，特别是对耐药性结核病。结核病治疗的一种新方法是治疗性疫苗接种。与预防性疫苗接种相反，预防性疫苗接种的目的是防止感染M。在结核病或发展为活动性结核病的情况下，治疗性疫苗接种的目的是作为结核病的预防性治疗或防止治愈后复发。几种候选的治疗性疫苗，使用灭活的全细胞或活的减毒分枝杆菌、分枝杆菌片段和病毒载体疫苗，目前正在进行临床试验。其他被动免疫模式，包括针对M.结核抗原处于不同的临床前发展阶段。在这里，我们将讨论这些不同的治疗方法及其拟议的作用机制。虽然治疗性疫苗接种用于治疗结核病的全部临床效用尚未建立，但它们作为有用的辅助疗法具有潜力。
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world’s deadliest bacterial infection, resulting in more than 1.4 million deaths annually. The emergence of drug-resistance to first-line antibiotic therapy poses a threat to successful treatment, and novel therapeutic options are required, particularly for drug-resistant tuberculosis. One modality emerging for TB treatment is therapeutic vaccination. As opposed to preventative vaccination – the aim of which is to prevent getting infected by M. tuberculosis or developing active tuberculosis, the purpose of therapeutic vaccination is as adjunctive treatment of TB or to prevent relapse following cure. Several candidate therapeutic vaccines, using killed whole-cell or live attenuated mycobacteria, mycobacterial fragments and viral vectored vaccines are in current clinical trials. Other modes of passive immunization, including monoclonal antibodies directed against M. tuberculosis antigens are in various pre-clinical stages of development. Here, we will discuss these various therapeutics and their proposed mechanisms of action. Although the full clinical utility of therapeutic vaccination for the treatment of tuberculosis is yet to be established, they hold potential as useful adjunct therapies.
登录
查看更多内容
影响因子：
5.5
作者：
Hatherill, Mark;Geldenhuys, Hendrik;Pienaar, Bernadette;Suliman, Sara;Chheng, Phalkun;Debanne, Sara M.;Hoft, Daniel F.;Boom, W. Henry;Hanekom, Willem A.;Johnson, John L.
通讯作者：
Johnson, John L.
影响因子：
7.3
作者：
Afkhami S;Villela AD;D'Agostino MR;Jeyanathan M;Gillgrass A;Xing Z
通讯作者：
Xing Z
影响因子：
6.4
作者：
Coler, Rhea N.;Bertholet, Sylvie;Reed, Steven G.
通讯作者：
Reed, Steven G.
影响因子：
--
作者：
Guirado, Evelyn;Gil, Olga;Cardona, Pere-Joan
通讯作者：
Cardona, Pere-Joan
影响因子：
5.8
作者：
Gengenbacher, Martin;Kaiser, Peggy;Kaufmann, Stefan H. E.
通讯作者：
Kaufmann, Stefan H. E.