Advancing Immunotherapeutic Vaccine Strategies Against Pulmonary Tuberculosis.
Advancing Immunotherapeutic Vaccine Strategies Against Pulmonary Tuberculosis.
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DOI：
10.3389/fimmu.2020.557809
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发表时间：
2020
影响因子：
7.3
通讯作者：
Xing Z
中科院分区：
文献类型：
--
作者：
Afkhami S;Villela AD;D'Agostino MR;Jeyanathan M;Gillgrass A;Xing Z
化学疗法干预仍然是治疗和控制结核病的主要策略。然而，治疗和患者相关因素之间复杂的相互作用导致治疗依从性差。这反过来又继续导致令人无法接受的高疾病复发率和越来越多的耐药结核病。因此，人们对同时改善治疗结果和缩短化疗持续时间的策略非常感兴趣。治疗性疫苗代表了一种这样的方法，其目的是通过加强和/或引发新的抗TB免疫应答来实现这一点，以加速疾病消退，缩短治疗持续时间，并提高治疗成功率。许多治疗性候选疫苗目前正在进行临床前和临床评估，显示出不同程度的疗效。通过剖析其成功和/或缺点的潜在机制/相关性，可以确定改进现有和未来候选疫苗的策略。这篇小型综述将讨论目前对治疗性结核病候选疫苗的理解，并讨论在推进其发展中可以实施的主要策略。
Chemotherapeutic intervention remains the primary strategy in treating and controlling tuberculosis (TB). However, a complex interplay between therapeutic and patient-related factors leads to poor treatment adherence. This in turn continues to give rise to unacceptably high rates of disease relapse and the growing emergence of drug-resistant forms of TB. As such, there is considerable interest in strategies that simultaneously improve treatment outcome and shorten chemotherapy duration. Therapeutic vaccines represent one such approach which aims to accomplish this through boosting and/or priming novel anti-TB immune responses to accelerate disease resolution, shorten treatment duration, and enhance treatment success rates. Numerous therapeutic vaccine candidates are currently undergoing pre-clinical and clinical assessment, showing varying degrees of efficacy. By dissecting the underlying mechanisms/correlates of their successes and/or shortcomings, strategies can be identified to improve existing and future vaccine candidates. This mini-review will discuss the current understanding of therapeutic TB vaccine candidates, and discuss major strategies that can be implemented in advancing their development.
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影响因子：
5.5
作者：
Cottingham, Matthew G.;Carroll, Miles W.
通讯作者：
Carroll, Miles W.
影响因子：
158.5
作者：
Conradie, Francesca;Diacon, Andreas H.;Spigelman, Melvin
通讯作者：
Spigelman, Melvin
DOI：
10.1038/mtm.2016.30
发表时间：
2016
期刊：
Molecular therapy. Methods & clinical development
影响因子：
--
作者：
Afkhami S;Yao Y;Xing Z
通讯作者：
Xing Z
影响因子：
6.4
作者：
Coler, Rhea N.;Bertholet, Sylvie;Reed, Steven G.
通讯作者：
Reed, Steven G.
影响因子：
11.3
作者：
Gengenbacher M;Kaufmann SH
通讯作者：
Kaufmann SH