Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
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DOI：
10.1371/journal.pone.0030265
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Takeda K
中科院分区：
文献类型：
--
作者：
Ishida Y;Sekine Y;Oguchi H;Chihara T;Miura M;Ichijo H;Takeda K
热休克（HS）反应是所有生物体生存所必需的。虽然HS反应的机制已经在细胞水平上得到了广泛的研究，但在生物体水平上却知之甚少。在这里，我们展示了蘑菇体（MB）在果蝇HS反应中的关键作用。线粒体磷酸酶Drosophila PGAM5（dPGAM5）的突变体表现出增加的脆弱性HS，这是逆转MB特异性表达的半胱天冬酶抑制剂p35，和类似的脆弱性诱导野生型苍蝇敲低MB dPGAM5。消除MB不影响野生型苍蝇的HS反应，但确实增加了dPGAM5缺陷苍蝇对HS的抗性。因此，MB可能具有一种依赖于中毒的毒性功能，dPGAM5对这种功能的抑制似乎对HS耐药性至关重要。
The heat shock (HS) response is essential for survival of all organisms. Although the machinery of the HS response has been extensively investigated at the cellular level, it is poorly understood at the level of the organism. Here, we show the crucial role of the mushroom body (MB) in the HS response in Drosophila. Null mutants of the mitochondrial phosphatase Drosophila PGAM5 (dPGAM5) exhibited increased vulnerability to HS, which was reversed by MB-specific expression of the caspase inhibitor p35, and similar vulnerability was induced in wild-type flies by knockdown of MB dPGAM5. Elimination of the MB did not affect the HS response of wild-type flies, but did increase the resistance of dPGAM5-deficient flies to HS. Thus, the MB may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for HS resistance.
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影响因子：
4.5
作者：
Imai Y;Kanao T;Sawada T;Kobayashi Y;Moriwaki Y;Ishida Y;Takeda K;Ichijo H;Lu B;Takahashi R
通讯作者：
Takahashi R
果蝇 IAP1 的时间调节决定了感觉器官发育中的 caspase 功能。
DOI：
10.1083/jcb.200905110
发表时间：
2009-10-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Koto A;Kuranaga E;Miura M
通讯作者：
Miura M
影响因子：
2.6
作者：
Lee, BP;Jones, BW
通讯作者：
Jones, BW
影响因子：
46.9
作者：
Kennerdell, JR;Carthew, RW
通讯作者：
Carthew, RW
影响因子：
11.4
作者：
Senoo-Matsuda, N;Igaki, T;Miura, M
通讯作者：
Miura, M