Age-, Site-, and Sex-Specific Normative Centile Curves for HR-pQCT-Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population.
Age-, Site-, and Sex-Specific Normative Centile Curves for HR-pQCT-Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population.
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DOI：
10.1002/jbmr.4116
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发表时间：
2020-11
影响因子：
6.2
通讯作者：
Xia, Weibo
中科院分区：
文献类型：
--
作者：
Yu, Fan;Xu, Yuping;Hou, Yanfang;Lin, Yuanyuan;Jiajue, Ruizhi;Jiang, Yan;Wang, Ou;Li, Mei;Xing, Xiaoping;Zhang, Li;Qin, Ling;Hsieh, Evelyn;Xia, Weibo
高分辨率外周定量CT(HR-pQCT)是一种先进的三维成像技术，有可能有助于骨折风险评估和骨质疏松的早期诊断。然而，到目前为止，还没有研究试图在中国大陆的个人中建立HR-pQCT测量的标准化参考范围，这大大限制了它的使用。在这项研究中，我们使用最新一代扫描仪(Sanco XtremeCT II，Sanco Medical AG，瑞士布鲁蒂塞伦)收集了863名年龄在20岁至80岁之间的健康中国男性和女性的HR-pQCT扫描数据。评估的参数包括体积骨密度、骨几何形状、骨微结构和骨强度。使用以年龄为唯一解释变量的位置、规模和形状的广义相加模型，建立了年龄、地点和性别的特定百分位数曲线。基于所建立的模型，也量化了不同参数随年龄的变化。出于临床目的，提供了特定年龄和特定百分位数或Z分数的HR-pQCT参数的期望值。我们发现，无论性别和部位，大多数骨小梁和骨强度参数在20岁时达到峰值，然后稳步下降。然而，大部分皮质骨丢失是在50岁以后观察到的。在这些指标中，皮质孔隙度的变化最大，总体上，半径的变化比胫骨的变化更显著，与男性相比，女性的变化更显著。建立这些标准化的HR-pQCT参考数据，将为内地中国阐明不同疾病状态或营养状况导致的微结构骨损伤的临床和研究应用提供重要依据。
High-resolution peripheral quantitative computed tomography (HR-pQCT) is an advanced 3D imaging technology that has the potential to contribute to fracture risk assessment and early diagnosis of osteoporosis. However, to date no studies have sought to establish normative reference ranges for HR-pQCT measures among individuals from the Chinese mainland, significantly restricting its use. In this study, we collected HR-pQCT scans from 863 healthy Chinese men and women aged 20 to 80 years using the latest-generation scanner (Scanco XtremeCT II, Scanco Medical AG, Brüttisellen, Switzerland). Parameters including volumetric bone mineral density, bone geometry, bone microarchitecture, and bone strength were evaluated. Age-, site-, and sex-specific centile curves were established using generalized additive models for location, scale, and shape with age as the only explanatory variable. Based on established models, age-related variations for different parameters were also quantified. For clinical purposes, the expected values of HR-pQCT parameters for a defined age and a defined percentile or Z-score were provided. We found that the majority of trabecular and bone strength parameters reached their peak at 20 years of age, regardless of sex and site, then declined steadily thereafter. However, most of the cortical bone loss was observed after the age of 50 years. Among the measures, cortical porosity changed most dramatically, and overall, changes were more notable at the radius than the tibia and among women compared with men. Establishing such normative HR-pQCT reference data will provide an important basis for clinical and research applications in mainland China aimed at elucidating microstructural bone damage driven by different disease states or nutritional status.
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影响因子：
6.2
作者：
Nicks, Kristy M.;Amin, Shreyasee;Atkinson, Elizabeth J.;Riggs, B. Lawrence;Melton, L. Joseph, III;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
影响因子：
5.8
作者：
Khosla, S;Riggs, BL;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
4
作者：
Agarwal, S.;Rosete, F.;Nishiyama, K. K.
通讯作者：
Nishiyama, K. K.
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
4
作者：
Hung, V. W. Y.;Zhu, T. Y.;Qin, L.
通讯作者：
Qin, L.