Neuroanatomical Correlates of Perceived Stress Controllability in Adolescents and Emerging Adults.
Neuroanatomical Correlates of Perceived Stress Controllability in Adolescents and Emerging Adults.
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DOI：
10.3758/s13415-022-00985-2
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发表时间：
2022-08
影响因子：
2.9
通讯作者：
Banich, Marie T.
中科院分区：
文献类型：
--
作者：
Fassett-Carman, Alyssa N.;Smolker, Harry;Hankin, Benjamin L.;Snyder, Hannah R.;Banich, Marie T.
关键词：
压力性生活事件可以预测大脑结构的变化和精神病理学的增加，但并非每个人都受到生活压力的影响。习得性无助理论认为，将生活压力感知为无法控制的会导致抑郁。有证据支持这一理论的青年，但影响的感知控制分歧的压力源类型的基础上：感知缺乏控制依赖（自我产生）的压力与更大的抑郁症状时，控制压力暴露的频率，但感知控制独立（非自我产生）的压力是没有。然而，目前尚不清楚对这些压力源类型的感知控制如何与大脑结构相关。我们在108名14-22岁的青少年和新兴成年人的样本中测试了对依赖和独立生活压力源缺乏控制（控制压力源暴露）是否与先验感兴趣区域（ROI; mPFC，海马，杏仁核）和整个皮层中的灰质（GM）相关。在整个样本中，对任何一种压力源类型的感知控制与ROI中的GM之间没有关联。然而，较少的感知控制依赖性压力与更大的杏仁核灰质体积在女性青年和更大的内侧前额叶皮层厚度在男性青年。此外，全皮层分析显示，对依赖性压力源的感知控制较少，与参与认知和情绪调节的皮层区域的GM厚度较大有关。因此，控制的评价有明显的关联与大脑形态，同时控制压力源的频率，突出了在未来的研究中区分这些方面的压力体验的重要性。
Stressful life events predict changes in brain structure and increases in psychopathology, but not everyone is equally affected by life stress. The learned helplessness theory posits that perceiving life stressors as uncontrollable leads to depression. Evidence supports this theory for youth, but the impact of perceived control diverges based on stressor type: perceived lack of control over dependent (self-generated) stressors is associated with greater depression symptoms when controlling for the frequency of stress exposure, but perceived control over independent (non-self-generated) stressors is not. However, it is unknown how perceived control over these stressor types is associated with brain structure. We tested whether perceived lack of control over dependent and independent life stressors, controlling for stressor exposure, is associated with gray matter (GM) in a priori regions of interest (ROIs; mPFC, hippocampus, amygdala) and across the cortex in a sample of 108 adolescents and emerging adults ages 14–22. There were no associations across the full sample between perceived control over either stressor type and GM in the ROIs. However, less perceived control over dependent stressors was associated with greater amygdala gray matter volume in female youth and greater medial prefrontal cortex thickness in male youth. Further, whole-cortex analyses revealed less perceived control over dependent stressors was associated with greater GM thickness in cortical regions involved in cognitive and emotional regulation. Thus, appraisals of control have distinct associations with brain morphology while controlling for stressor frequency, highlighting the importance of differentiating between these aspects of the stress experience in future research.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
10.6
作者：
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通讯作者：
Sinha, Rajita
影响因子：
3.7
作者：
Fassett-Carman, Alyssa;Hankin, Benjamin L.;Snyder, Hannah R.
通讯作者：
Snyder, Hannah R.
影响因子：
5.7
作者：
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通讯作者：
Brain Development Cooperative Group
影响因子：
6.6
作者：
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通讯作者：
Snyder, Hannah R.