Age-Related Changes in Dynamic Iris Behavior Assessed Using a Programmable Closed-Loop Iris Control System.
Age-Related Changes in Dynamic Iris Behavior Assessed Using a Programmable Closed-Loop Iris Control System.
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DOI：
10.1167/tvst.11.11.9
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发表时间：
2022-11-01
影响因子：
3
通讯作者：
Xu, Benjamin Y.
中科院分区：
文献类型：
--
作者：
Apolo, Galo;Lazkani, Naim;Zhou, Sarah;Song, Abe E.;Pardeshi, Anmol A.;Torossian, Lernik;Nguyen, Kent;Weinreb, Robert N.;Xu, Benjamin Y.
本研究的目的是开发和测试一种可编程闭环系统，用于跟踪、调节和评估动态虹膜行为，包括在中间扩张位置。通过定制ANTERION OCT设备（Heidelberg Engineering，Heidelberg，德国）开发了可编程闭环虹膜控制系统。开发定制软件以存储相机和光学相干断层扫描（OCT）图像，跟踪瞳孔直径（PD），控制发光二极管（LED），并调制环境照明以实时将虹膜维持在扩张、收缩或中等扩张位置。研究参与者接受了连续3次65秒的扫描。以峰值收缩速度（PCV）和中度扩张虹膜活动（MDIA）的形式计算并离线分析动态虹膜行为。在58例受试者中，56例（96.6%）符合分析条件，基于达到并维持平均PD在计算的中度扩张PD的±10%范围内。平均参与者年龄为49.8 ± 18.9岁。平均PCV为3.92 ± 0.83 mm/s，平均MDIA为0.37 ± 0.15 mm，计算的中间扩张PD与实际测量的中间扩张PD的平均差值为0.166 ± 0.192 mm，PCV与年龄呈显著负相关（斜率=-0.022，P < 0.001）和MDIA与年龄（斜率=-0.004，P < 0.001）。成功率较低（69.0%），但动态虹膜行为与年龄之间的关系相似，基于实现和维持平均PD在计算的中度扩张PD的±5%范围内。可编程闭环虹膜控制系统可以调节动态虹膜行为并将虹膜保持在中间扩张位置。瞳孔收缩速度和虹膜活动在中间扩张位置随着年龄的增长而下降。该系统可应用于研究涉及虹膜的动态疾病过程，并建立新的生物计量措施，可作为急性和慢性原发性闭角型青光眼（PACG）的危险因素。
The purpose of this study was to develop and test a programmable closed-loop system for tracking, modulating, and assessing dynamic iris behavior, including in the mid-dilated position. A programmable closed-loop iris control system was developed by customizing an ANTERION OCT device (Heidelberg Engineering, Heidelberg, Germany). Custom software was developed to store camera and optical coherence tomography (OCT) images, track pupillary diameter (PD), control a light-emitting diode (LED), and modulate ambient lighting to maintain the iris in a dilated, constricted, or mid-dilated position in real-time. Study participants underwent 3 consecutive 65-second scan sessions. Dynamic iris behavior in the form of peak constriction velocity (PCV) and mid-dilated iris activity (MDIA) were calculated and analyzed offline. Among 58 participants, 56 (96.6%) were eligible for analysis based on achieving and maintaining mean PD within ±10% of the calculated mid-dilated PD. Mean participant age was 49.8 ± 18.9 years. Mean PCV was 3.92 ± 0.83 mm/s, and mean MDIA was 0.37 ± 0.15 mm. The mean difference between the calculated and achieved mid-dilated PD was 0.166 ± 0.192 mm. There were significant negative correlations between PCV and age (slope = −0.022, P < 0.001) and MDIA and age (slope = −0.004, P < 0.001). Success rates were lower (69.0%) but relationships between dynamic iris behavior and age were similar based on achieving and maintaining mean PD within ±5% of the calculated mid-dilated PD. A programmable closed-loop iris control system can modulate dynamic iris behavior and maintain the iris in a mid-dilated position. Pupillary constriction velocity and iris activity in the mid-dilated position decrease with age. This system can be applied to study dynamic disease processes involving the iris and establish novel biometric measures that could serve as risk factors for acute and chronic primary angle closure glaucoma (PACG).
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影响因子：
2
作者：
Xu BY;Mai DD;Penteado RC;Saunders L;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
13.7
作者：
Xu BY;Friedman DS;Foster PJ;Jiang Y;Porporato N;Pardeshi AA;Jiang Y;Munoz B;Aung T;He M
通讯作者：
He M
影响因子：
4.4
作者：
Liang, Yuanbo;Friedman, David S.;Wang, Ning Li
通讯作者：
Wang, Ning Li
影响因子：
13.7
作者：
Baskaran, Mani;Kumar, Rajesh S.;Aung, Tin
通讯作者：
Aung, Tin
DOI：
10.1007/s00417-012-1934-7
发表时间：
2012-09-01
影响因子：
2.7
作者：
Zheng, Ce;Cheung, Carol Y.;Aung, Tin
通讯作者：
Aung, Tin