The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.
The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.
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DOI：
10.1084/jem.20081829
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发表时间：
2009-02-16
期刊：
影响因子：
--
通讯作者：
Kedl RM
中科院分区：
文献类型：
--
作者：
Haluszczak C;Akue AD;Hamilton SE;Johnson LD;Pujanauski L;Teodorovic L;Jameson SC;Kedl RM
记忆T细胞对病原体和肿瘤的反应优于它们的初始对应物。记忆通常是通过对外来抗原的免疫反应产生的，但功能记忆T细胞也可以由初始细胞通过稳态机制产生。使用最近开发的一种方法，我们研究了CD8 T细胞，它对模型（卵清蛋白）和病毒（HSV，牛痘）抗原具有特异性，在未免疫的小鼠中发现了一个携带记忆细胞标记的亚群。基于它们的表型标记和它们在无菌小鼠中的存在，这些预先存在的记忆样CD44hi CD8 T细胞可能是通过生理稳态增殖而不是对环境微生物的反应而产生的。这些缺乏抗原的记忆型CD8 T细胞表现出几种与CD44lo细胞不同的功能，包括在T细胞刺激后快速开始增殖和暴露于促炎细胞因子后快速产生IFN-γ。总的来说，这些数据表明，未引物的抗原特异性CD8 T细胞库包含没有抗原的细胞，这些细胞表现出记忆细胞的表型和功能特征。
Memory T cells exhibit superior responses to pathogens and tumors compared with their naive counterparts. Memory is typically generated via an immune response to a foreign antigen, but functional memory T cells can also be produced from naive cells by homeostatic mechanisms. Using a recently developed method, we studied CD8 T cells, which are specific for model (ovalbumin) and viral (HSV, vaccinia) antigens, in unimmunized mice and found a subpopulation bearing markers of memory cells. Based on their phenotypic markers and by their presence in germ-free mice, these preexisting memory-like CD44hi CD8 T cells are likely to arise via physiological homeostatic proliferation rather than a response to environmental microbes. These antigen-inexperienced memory phenotype CD8 T cells display several functions that distinguish them from their CD44lo counterparts, including a rapid initiation of proliferation after T cell stimulation and rapid IFN-γ production after exposure to proinflammatory cytokines. Collectively, these data indicate that the unprimed antigen-specific CD8 T cell repertoire contains antigen-inexperienced cells that display phenotypic and functional traits of memory cells.
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影响因子：
32.4
作者：
Ernst, B;Lee, DS;Surh, CD
通讯作者：
Surh, CD
DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
4.4
作者：
Kieper, WC;Prlic, M;Jameson, SC
通讯作者：
Jameson, SC
影响因子：
5.4
作者：
KELLY, JM;STERRY, SJ;CARBONE, FR
通讯作者：
CARBONE, FR
DOI：
10.1084/jem.186.9.1407
发表时间：
1997-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hamann D;Baars PA;Rep MH;Hooibrink B;Kerkhof-Garde SR;Klein MR;van Lier RA
通讯作者：
van Lier RA