Toll-like receptor -1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.
Toll-like receptor -1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.
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Toll 样受体 -1、-2 和 -6 多态性与肺结核易感性：系统评价和荟萃分析
DOI：
10.1371/journal.pone.0063357
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li JC
中科院分区：
文献类型：
--
作者：
Zhang Y;Jiang T;Yang X;Xue Y;Wang C;Liu J;Zhang X;Chen Z;Zhao M;Li JC
背景：大量研究探讨了Toll样受体(Toll-like Receptor，TLR)基因多态性是否与不同人群对结核病的易感性有关。然而，结果并不一致，也没有定论。方法检索PubMed、EMBASE、Medline(OVID)、ISI Web of Knowledge和中国国家知识基础设施(CNKI)。采用不同的遗传模型对TLR1G1805T、TLR2 T597C、T1350C、G2258A和TLR6C745T基因多态性与结核病发病风险的关系进行Meta分析。结果共纳入14篇文献中的16篇研究。在Meta分析中，TLR2 2258AA(AA vs AG+AG，OR 5.82，95%CI 1.30~26.16，P = 0.02)和TLR6 745TT(TT vs CT+CC，OR 0.61，95%CI 0.39~0.97，P = 0.04)与结核病的危险性显著相关。在按种族划分的亚组分析中，携带TLR1805T等位基因的非洲人和美国西班牙裔受试者对结核病的易感性增加，而携带TLR2 2258A等位基因的亚洲人和欧洲受试者对结核病的易感性增加。结论荟萃分析表明TLR2 G2258A与结核病风险增加有关，特别是在亚洲人和欧洲人中。TLR1G1805T与非洲人和美国拉美裔美国人中结核病的增加有关。TLR6 C745T与结核病风险降低相关。我们的系统综述和荟萃分析报告了一个有趣的初步结论，但这必须通过未来在不同人群中进行的大规模和功能研究来验证。
Background A large number of studies have investigated whether polymorphisms in the Toll-like receptor (TLR) genes are implicated in susceptibility to tuberculosis (TB) in different populations. However, the results are inconsistent and inconclusive. Methods A literature search was conducted using the PubMed, EMBASE, Medline (Ovid), ISI Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI). A meta-analysis on the associations between the TLR1 G1805T, TLR2 T597C, T1350C, G2258A, and TLR6 C745T polymorphisms and TB risk was carried out by comparison using different genetic models. Results In total, 16 studies from 14 articles were included in this review. In meta-analysis, significant associations were observed between the TLR2 2258AA (AA vs. AG+AG, OR 5.82, 95% CI 1.30–26.16, P = 0.02) and TLR6 745TT (TT vs. CT+CC, OR 0.61, 95% CI 0.39–0.97, P = 0.04) polymorphisms and TB risk. In the subgroup analysis by ethnicity, Africans and American Hispanic subjects with the TLR1 1805T allele had an increased susceptibility, whereas Asian and European subjects with the TLR2 2258A allele had an increased susceptibility to TB. Conclusions The meta-analysis indicated that TLR2 G2258A is associated with increased TB risk, especially in Asians and Europeans. TLR1 G1805T is associated with increased TB in Africans and American Hispanics. TLR6 C745T is associated with decreased TB risk. Our systematic review and meta-analysis reported an interesting preliminary conclusion, but this must be validated by future large-scale and functional studies in different populations.
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结核分枝杆菌对抗原呈递的调节：Toll 样受体的作用。
DOI：
10.1038/nrmicro2321
发表时间：
2010-04
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Johnson, Christopher M.;Lyle, Elizabeth A.;Tapping, Richard I.
通讯作者：
Tapping, Richard I.
影响因子：
--
作者：
Chen YC;Hsiao CC;Chen CJ;Chin CH;Liu SF;Wu CC;Eng HL;Chao TY;Tsen CC;Wang YH;Lin MC
通讯作者：
Lin MC
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG
影响因子：
3.7
作者：
Etokebe, G. E.;Skjeldal, F.;Dembic, Z.
通讯作者：
Dembic, Z.