Functional connectivity in blood oxygenation level-dependent and cerebral blood volume-weighted resting state functional magnetic resonance imaging in the rat brain.
Functional connectivity in blood oxygenation level-dependent and cerebral blood volume-weighted resting state functional magnetic resonance imaging in the rat brain.
复制标题
DOI：
10.1002/jmri.22295
复制
发表时间：
2010-09
影响因子：
4.4
通讯作者：
Keilholz, Sheila D.
中科院分区：
文献类型：
--
作者：
Magnuson, Matthew;Majeed, Wacjas;Keilholz, Sheila D.
目的：直接比较BOLD和CBV加权fMRI在麻醉大鼠中获得的功能连通性和时空动力学。10只大鼠获得了一系列的BOLD图像，然后是注射超小氧化铁颗粒产生的CBV加权图像。对BOLD和CBV加权静息状态扫描的功能连通性、光谱信息和时空动力学进行了比较。与CBV加权扫描相比，BOLD扫描显示出更高的交叉相关值，但相关的空间模式相似。BOLD谱包含均匀分布在整个低频范围内的功率，而CBV功率谱显示出局域在~0.2赫兹的高功率峰值。BOLD和CBV静息状态扫描都显示了类似的沿着大脑皮质从SII到MI的活动传播波；然而，这些波在BOLD扫描中比CBV扫描中更频繁地被检测到。虽然CBV信号的功率谱与BOLD信号的功率谱不同，但这两种模式的连通性地图和时空动力学都是相似的。进一步的实验应该解决自发神经活动、局部新陈代谢变化和血流动力学波动之间的关系，以阐明BOLD和CBV信号的来源。
To directly compare functional connectivity and spatiotemporal dynamics acquired with BOLD and CBV-weighted fMRI in anesthetized rats. A series of BOLD images were acquired in 10 rats followed by CBV-weighted images created by injection of ultra-small iron oxide particles. Functional connectivity, spectral information, and spatiotemporal dynamics were compared for the BOLD and CBV-weighted resting state scans. BOLD scans exhibited higher cross-correlation values compared to CBV-weighted scans, but the spatial patterns of correlation were similar. The BOLD spectrum contains power evenly distributed throughout the low frequency range while the CBV power spectrum exhibited a high power peak localized to ~0.2 Hz. Both BOLD and CBV resting state scans showed similar propagating waves of activity along the cortex from the SII toward MI; however, these waves were detected more often in BOLD scans than in CBV scans. While the power spectrum of the CBV signal is different from that of the BOLD signal, both connectivity maps and spatiotemporal dynamics are similar for the two modalities. Further experiments should address the relationship between spontaneous neural activity, local changes in metabolism, and hemodynamic fluctuations to elucidate the origins of the BOLD and CBV signals.
登录
查看更多内容
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
DOI：
10.1073/pnas.0705791104
发表时间：
2007-11-13
影响因子：
11.1
作者：
Lu, Hanbing;Zuo, Yantao;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
4.8
作者：
Wang, Kun;Liang, Meng;Jiang, Tianzi
通讯作者：
Jiang, Tianzi
影响因子：
5.7
作者：
Weber, R;Ramos-Cabrer, P;Hoehn, M
通讯作者：
Hoehn, M
影响因子：
3.3
作者：
Keilholz, SD;Silva, AC;Koretsky, AP
通讯作者：
Koretsky, AP