Association between paraoxonase gene and stroke in the Han Chinese population.
Association between paraoxonase gene and stroke in the Han Chinese population.
复制标题
对氧磷酶基因与中国汉族人群脑卒中的相关性
DOI：
10.1186/1471-2350-14-16
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发表时间：
2013-01-28
影响因子：
--
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhang G;Li W;Li Z;Lv H;Ren Y;Ma R;Li X;Kang X;Shi Y;Sun Y
背景人类对氧磷酶(PON)基因家族有三种亚型：PON1、PON2和PON3。这些基因被认为是脑血管疾病的潜在危险因素，可以防止低密度脂蛋白的氧化修饰和动脉粥样硬化。本研究旨在探讨这三种基因突变与汉族人全卒中、缺血性卒中和出血性卒中发病风险的关系。方法共1016名受试者，包括508名健康对照和498名患者(其中328名为缺血性卒中，170名为出血性卒中)。对涵盖PON基因的11个单核苷酸多态(SNPs)进行了基因分型和统计分析。结果在−基因启动子区存在rs705381(rs662，OR= 0.0007，OR= 0.57[95%CI = 0.41-0.79])与总卒中和缺血性卒中(P调整= 0.0017，OR= 0.54[95%CI = 0.37-0.79])显著相关，但与出血性卒中无关。Rs854571(−824)与总中风之间也存在名义上的关联。Meta分析显示rs662与缺血性卒中有显著的名义相关性，但在单点关联研究中没有证据表明rs662与缺血性卒中风险相关。结论PON1基因多态性可能是卒中的危险因素。
BackgroundThe human paraoxonase (PON) gene family has three isoforms:PON1,PON2andPON3. These genes are implicated as potential risk factors of cerebrovascular disease and can prevent oxidative modification of low-density lipoproteins and atherosclerosis. This study evaluated the association between the genetic variants of all threePONgenes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population.MethodsA total of 1016 subjects were recruited, including 508 healthy controls and 498 patients (328 with ischemic stroke and 170 with hemorrhagic stroke). A total of 11 single nucleotide polymorphisms (SNPs) covering thePONgenes were genotyped for statistical analysis. Two of the 11 SNPs (rs662 and rs854560) were contextualized in a meta-analysis of ischemic stroke.ResultsThe presence of rs705381 (−162) in the promoter region ofPON1was significantly associated with total stroke (Padjusted= 0.0007,OR= 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (Padjusted= 0.0017,OR= 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke. There was also a nominal association between rs854571 (−824) and total stroke. Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study.ConclusionsThese findings indicate that polymorphisms ofPON1gene may be a risk factor of stroke.
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影响因子：
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作者：
Martinelli N;Micaglio R;Consoli L;Guarini P;Grison E;Pizzolo F;Friso S;Trabetti E;Pignatti PF;Corrocher R;Olivieri O;Girelli D
通讯作者：
Girelli D
副氧酶1多态性和缺血性中风风险：系统评价和荟萃分析。
DOI：
10.1097/gim.0b013e3181ee81c6
发表时间：
2010-10
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Dahabreh IJ;Kitsios GD;Kent DM;Trikalinos TA
通讯作者：
Trikalinos TA
影响因子：
9.8
作者：
Brophy, VH;Jampsa, RL;Furlong, CE
通讯作者：
Furlong, CE
影响因子：
8.7
作者：
Kozarsky, KF;Donahee, MH;Rader, DJ
通讯作者：
Rader, DJ
DOI：
10.1097/00008571-200102000-00009
发表时间：
2001-02-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Brophy, VH;Hastings, MD;Furlong, CE
通讯作者：
Furlong, CE