Stereocomplexation of Poly(Lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels.
Stereocomplexation of Poly(Lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels.
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DOI：
10.3390/polym12102204
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发表时间：
2020-09-25
期刊：
影响因子：
5
通讯作者：
Liu S
中科院分区：
文献类型：
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作者：
Wang Z;Wu J;Shi X;Song F;Gao W;Liu S
Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability.
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影响因子：
4.6
作者：
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通讯作者：
Landfester, Katharina
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
通讯作者：
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