Tumors in F344 rats by oral administration of 1,3-diethyltriazene.
Tumors in F344 rats by oral administration of 1,3-diethyltriazene.
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口服 1,3-二乙基三氮烯对 F344 大鼠产生肿瘤。
DOI：
10.1016/0304-3835(87)90035-8
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发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
Michejda,CJ
中科院分区：
文献类型：
--
作者：
SmithJr,RH;Kovatch,RM;Lijinsky,W;Thomas,BJ;Michejda,CJ
A group of 20 male F344 rats was given by gavage a solution of 2.5 mg of 1,3-diethyltriazene in 0.2 ml corn oil twice a week for 20 weeks. Diethyltriazene is very unstable in hydroxylic solvents, but when administered in oil by gavage it induced tumors in almost all of the treated animals, 16 of which had neoplasms of the forestomach; 13 of which were carcinomas. In addition 9 rats had adenomas of the nasal mucosa, two had alveolarbronchiolar adenomas of the lung, one had a carcinoma of the esophagus and one an adenocarcinoma of the ileum. Half of the rats had died by week 56 of the experiment, the first at week 40 and the last at week 73. The induction of tumors at sites distant from the stomach indicate that diethyltriazene is more stable in the body than would be predicted from its chemical behavior. Although diethyltriazene is a protected alkyldiazonium ion, its carcinogenic effects in rats differ from ethylnitrosoureas, which are also ethylating agents.
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1-乙基-1-亚硝基-3-羟乙基脲和1-羟乙基-1-亚硝基-3-乙基脲对大鼠有相似的致癌作用。
影响因子：
4.7
作者：
Lijinsky,W;Singer,GM;Kovatch,RM
通讯作者：
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DOI：
--
发表时间：
1980
期刊：
Mutation research
影响因子：
--
作者：
D. H. Sieh;A. W. Andrews;C. Michejda
通讯作者：
C. Michejda
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影响因子：
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作者：
W. Lijinsky;M. D. Reuber
通讯作者：
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N-亚硝基-N-烷基氨基甲酸酯对 Sprague-Dawley 大鼠的致癌作用。
影响因子：
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作者：
W. Lijinsky;H. W. Taylor
通讯作者：
H. W. Taylor
三烷基三氮烯的酸催化分解：受保护的烷基重氮离子
影响因子：
15
作者：
D. H. Sieh;C. Michejda
通讯作者：
C. Michejda