Do oxytocin neurones affect feeding?

Do oxytocin neurones affect feeding?
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催产素神经元会影响进食吗?

DOI:
10.1111/jne.13035
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发表时间:
2021
影响因子:
3.2
通讯作者:
Worth AA
Worth AA
中科院分区:
医学3区
文献类型:
--
作者:
Worth AA

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关于催产素对进食行为的影响的研究已经有很长的历史了。经典的观点是,至少在啮齿动物中,神经激素是厌氧性的,尽管人类的数据并不那么明确。同样,催产素的生理作用也存在争议。因此,尽管药理学、解剖学和生理学数据表明催产素可能在饱腹感信号传导中起作用,但这一观点并未得到利用催产素神经元基因记录和操作的最新研究的支持。在这里,我们避免讨论催产素的药理作用,并从争论的双方检查证据,关于内源性催产素系统是否在正常喂养的调节中起作用。
There has been a long history of research on the effects of oxytocin on feeding behaviour. The classic‐held view is that the neurohormone is anorexigenic at least in rodents, although the data for humans are not so clear cut. Likewise, a physiological role for oxytocin is disputed. Thus, although pharmacological, anatomical and physiological data suggest oxytocin may have a function in satiety signalling, this view is not supported by the latest research using the genetic recording and manipulation of oxytocin neurones. Here, we avoid a discussion of the pharmacological effects of oxytocin and examine evidence, from both sides of the argument, concerning whether the endogenous oxytocin system has a role in the regulation of normal feeding.
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