A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice.
A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice.
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一种新型单克隆抗体，可有效对抗猪系病毒和 2009 年大流行 H1N1 流感病毒对小鼠的致命攻击。
DOI：
10.1016/j.virol.2011.06.021
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Perez,DanielR
中科院分区：
文献类型：
--
作者：
Shao,Hongxia;Ye,Jianqiang;Vincent,AmyL;Edworthy,Nicole;Ferrero,Andrea;Qin,Aijian;Perez,DanielR
The HA protein of the 2009 pandemic H1N1 viruses (H1N1pdm) is antigenically closely related to the HA of classical North American swine H1N1 influenza viruses (cH1N1). Since 1998, through mutation and reassortment of HA genes from human H3N2 and H1N1 influenza viruses, swine influenza strains are undergoing substantial antigenic drift and shift. In this report we describe the development of a novel monoclonal antibody (S-OIV-3B2) that shows high hemagglutination inhibition (HI) and neutralization titers not only against H1N1pdm, but also against representatives of the α, β, and γ clusters of swine-lineage H1 influenza viruses. Mice that received a single intranasal dose of S-OIV-3B2 were protected against lethal challenge with either H1N1pdm or cH1N1 virus. These studies highlight the potential use of S-OIV-3B2 as effective intranasal prophylactic or therapeutic antiviral treatment for swine-lineage H1 influenza virus infections.
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影响因子：
8.9
作者：
Venkata, Chakradhar;Sampathkumar, Priya;Afessa, Bekele
通讯作者：
Afessa, Bekele
DOI：
10.1136/bmj.b5213
发表时间：
2009-12-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Donaldson LJ;Rutter PD;Ellis BM;Greaves FE;Mytton OT;Pebody RG;Yardley IE
通讯作者：
Yardley IE
从火鸡中分离出的大流行 H1N1 流感病毒的分子特征以及人类 pH1N1 分离株在火鸡中的致病性
影响因子：
3.1
作者：
Y. Berhane;D. Ojkic;J. Neufeld;M. Leith;T. Hisanaga;H. Kehler;Á. Ferencz;H. Wojcinski;C. Cottam;M. Suderman;K. Handel;S. Alexandersen;J. Pasick
通讯作者：
J. Pasick
影响因子：
1.6
作者：
Vincent, Amy L.;Ma, Wenjun;Janke, Bruce H.
通讯作者：
Janke, Bruce H.
2009年大流行流感病毒是否起源于人类？
影响因子：
3.1
作者：
H. Weingartl
通讯作者：
H. Weingartl