Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
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DOI：
10.1016/j.ceb.2013.01.008
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发表时间：
2013-04
影响因子：
7.5
通讯作者：
Derynck, Rik
中科院分区：
文献类型：
--
作者：
Lamouille, Samy;Subramanyam, Deepa;Blelloch, Robert;Derynck, Rik
上皮-间充质转化（EMT）和逆过程，间充质-上皮转化（MET），在发育和干细胞多能性的调节过程中是必不可少的，但这些过程也在病理学背景下被激活，如纤维化和癌症进展。在EMT和MET中，不同的信号通路通过在转录、转录后、翻译和翻译后水平的调节在EMT和MET程序的起始和进展中合作。microRNA最近成为EMT和MET的有效调节剂，其能够靶向参与上皮完整性或间充质性状的多个组分。通过影响EMT和MET过程，microRNA参与调节干细胞多能性和控制肿瘤进展。
Epithelial–mesenchymal transition (EMT) and the reverse process, mesenchymal–epithelial transition (MET), are essential during development and in the regulation of stem cell pluripotency, yet these processes are also activated in pathological contexts, such as in fibrosis and cancer progression. In EMT and MET, diverse signaling pathways cooperate in the initiation and progression of the EMT and MET programs, through regulation at transcriptional, post-transcriptional, translational, and post-translational levels. MicroRNAs recently emerged as potent regulators of EMT and MET, with their abilities to target multiple components involved in epithelial integrity or mesenchymal traits. By affecting EMT and MET processes, microRNAs are involved in the regulation of stem cell pluripotency and the control of tumor progression.
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影响因子：
5.3
作者：
Kong, William;Yang, Hua;Cheng, Jin Q.
通讯作者：
Cheng, Jin Q.
影响因子：
46.9
作者：
Ma L;Reinhardt F;Pan E;Soutschek J;Bhat B;Marcusson EG;Teruya-Feldstein J;Bell GW;Weinberg RA
通讯作者：
Weinberg RA
影响因子：
5.7
作者：
Ru, Peng;Steele, Robert;Ray, Ratna B.
通讯作者：
Ray, Ratna B.
影响因子：
11.2
作者：
Bracken, Cameron P.;Gregory, Philip A.;Goodall, Gregory J.
通讯作者：
Goodall, Gregory J.
影响因子：
21.3
作者：
Ma, Li;Young, Jennifer;Prabhala, Harsha;Pan, Elizabeth;Mestdagh, Pieter;Muth, Daniel;Teruya-Feldstein, Julie;Reinhardt, Ferenc;Onder, Tamer T.;Valastyan, Scott;Westermann, Frank;Speleman, Frank;Vandesompele, Jo;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.