Magnetic resonance lung function--a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial.
Magnetic resonance lung function--a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial.
复制标题
磁共振肺功能 - 肺成像和功能评估的突破？幻影研究和临床试验。
DOI：
10.1186/1465-9921-7-106
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发表时间：
2006-08-06
影响因子：
5.8
通讯作者：
Rupprecht T
中科院分区：
文献类型：
--
作者：
Zapke M;Topf HG;Zenker M;Kuth R;Deimling M;Kreisler P;Rauh M;Chefd'hotel C;Geiger B;Rupprecht T
慢性肺部疾病是公共卫生中的一个主要问题。因此，使用无电离辐射的成像技术进行一系列肺部评估，并提供局部功能损害的早期信息，将是一个相当重要的发展。磁共振成像（MRI）是一个强大的工具，静态和动态成像的许多器官。然而，由于肺的低含水量和空气-组织界面处明显的伪影，其在肺成像中的应用受到限制。已经进行了许多尝试，通过吸入超极化气体或响应MRI的钆气雾剂来可视化局部通气。这些方法都不适用于广泛的临床使用，因为它们需要特定的设备。我们以前已经表明，低场MRI可用于肺部的静态成像。在这里，我们表明，数学处理的数据来自连续的MRI扫描在呼吸周期产生良好的质量图像的局部通气没有任何造影剂。对85例患者进行了体模研究和调查。幻影研究证实了我们的理论考虑。在99例患者的研究中，肺功能检查和MR通气测量结果具有良好的相关性（r = 0.8; p ≤ 0.001）。可见小的通气缺陷。通过这种方法，通气缺陷可以在任何成像或肺功能测试指示疾病之前很久就被诊断出来。这种令人惊讶的简单方法可以很容易地纳入临床常规，并可能成为肺成像和功能评估的突破。
Chronic lung diseases are a major issue in public health. A serial pulmonary assessment using imaging techniques free of ionizing radiation and which provides early information on local function impairment would therefore be a considerably important development. Magnetic resonance imaging (MRI) is a powerful tool for the static and dynamic imaging of many organs. Its application in lung imaging however, has been limited due to the low water content of the lung and the artefacts evident at air-tissue interfaces. Many attempts have been made to visualize local ventilation using the inhalation of hyperpolarized gases or gadolinium aerosol responding to MRI. None of these methods are applicable for broad clinical use as they require specific equipment. We have shown previously that low-field MRI can be used for static imaging of the lung. Here we show that mathematical processing of data derived from serial MRI scans during the respiratory cycle produces good quality images of local ventilation without any contrast agent. A phantom study and investigations in 85 patients were performed. The phantom study proved our theoretical considerations. In 99 patient investigations good correlation (r = 0.8; p ≤ 0.001) was seen for pulmonary function tests and MR ventilation measurements. Small ventilation defects were visualized. With this method, ventilation defects can be diagnosed long before any imaging or pulmonary function test will indicate disease. This surprisingly simple approach could easily be incorporated in clinical routine and may be a breakthrough for lung imaging and functional assessment.
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影响因子：
9.6
作者：
Zaporozhan, J;Ley, S;Kauczor, HU
通讯作者：
Kauczor, HU
影响因子：
19.5
作者：
Hermosillo, G;Chefd'Hotel, C;Faugeras, O
通讯作者：
Faugeras, O
影响因子：
5.9
作者：
Rupprecht, T;Böwing, B;Wagner, M
通讯作者：
Wagner, M
DOI：
10.1002/mpo.1247
发表时间：
2001-12-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
Wagner, M;Kuth, R;Rupprecht, T
通讯作者：
Rupprecht, T
DOI：
10.1097/00002142-200306000-00003
发表时间：
2003-06-01
期刊：
Topics in magnetic resonance imaging : TMRI
影响因子：
--
作者：
Altes, Talissa A;de Lange, Eduard E
通讯作者：
de Lange, Eduard E