Diffusion tensor imaging of post mortem multiple sclerosis brain.
Diffusion tensor imaging of post mortem multiple sclerosis brain.
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DOI：
10.1016/j.neuroimage.2006.12.010
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发表时间：
2007-04-01
期刊：
影响因子：
5.7
通讯作者：
Miller, David H.
中科院分区：
文献类型：
--
作者：
Schmierer, Klaus;Wheeler-Kingshott, Claudia A. M.;Boulby, Phil A.;Scaravilli, Francesco;Altmann, Daniel R.;Barker, Gareth J.;Tofts, Paul S.;Miller, David H.
磁共振成像（MRI）被用于探测多发性硬化症（MS）患者的中枢神经系统（CNS），多发性硬化症是一种慢性脱髓鞘疾病。传统的T2加权MRI（cMRI）在很大程度上无法预测患者的残疾程度。这一缺点可能是由于cMRI对临床相关病理学的特异性较差。扩散张量成像（DTI）已显示出更具体的MS病理承诺。在这项研究中，我们研究了髓鞘含量，轴突计数和胶质增生的组织学指标之间的关联，和两个措施的DTI（平均扩散率[MD]和分数各向异性[FA]），在未固定的死后MS脑使用1.5 T MR系统。MD和FA均显着降低，在死后MS脑相比，发表的数据在体内获得的。然而，在活体研究中描述的白色物质病变（WML）和外观正常的白色物质（NAWM）之间的MD和FA差异在死后脑的这项研究中得到了保留：WML的平均MD为0.35 × 10− 3 mm 2/s（SD，0.09）与NAWM中的0.22（0.04）; WML中的FA为0.22（0.06）与NAWM中的0.38（0.13）。髓鞘含量（Trmyelin）与（i）FA（r =-0.79，p < 0.001），（ii）MD（r = 0.68，p < 0.001）和（iii）轴突计数（r =-0.81，p < 0.001）之间存在相关性。多元回归表明，这些相关性在很大程度上解释了轴突计数与（i）FA（r = 0.70，p < 0.001）和（ii）MD（r =-0.66，p < 0.001）的明显相关性。总之，这项研究表明，FA和MD的影响髓鞘含量和-在较小程度上-轴突计数在死后MS脑。
Magnetic resonance imaging (MRI) is being used to probe the central nervous system (CNS) of patients with multiple sclerosis (MS), a chronic demyelinating disease. Conventional T2-weighted MRI (cMRI) largely fails to predict the degree of patients' disability. This shortcoming may be due to poor specificity of cMRI for clinically relevant pathology. Diffusion tensor imaging (DTI) has shown promise to be more specific for MS pathology. In this study we investigated the association between histological indices of myelin content, axonal count and gliosis, and two measures of DTI (mean diffusivity [MD] and fractional anisotropy [FA]), in unfixed post mortem MS brain using a 1.5-T MR system. Both MD and FA were significantly lower in post mortem MS brain compared to published data acquired in vivo. However, the differences of MD and FA described in vivo between white matter lesions (WMLs) and normal-appearing white matter (NAWM) were retained in this study of post mortem brain: average MD in WMLs was 0.35 × 10− 3 mm2/s (SD, 0.09) versus 0.22 (0.04) in NAWM; FA was 0.22 (0.06) in WMLs versus 0.38 (0.13) in NAWM. Correlations were detected between myelin content (Trmyelin) and (i) FA (r = − 0.79, p < 0.001), (ii) MD (r = 0.68, p < 0.001), and (iii) axonal count (r = − 0.81, p < 0.001). Multiple regression suggested that these correlations largely explain the apparent association of axonal count with (i) FA (r = 0.70, p < 0.001) and (ii) MD (r = − 0.66, p < 0.001). In conclusion, this study suggests that FA and MD are affected by myelin content and – to a lesser degree – axonal count in post mortem MS brain.
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影响因子：
14.5
作者：
BARNES, D;MUNRO, PMG;MCDONALD, WI
通讯作者：
MCDONALD, WI
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
DOI：
10.1602/neurorx.2.2.167
发表时间：
2005-04-01
期刊：
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Bammer, Roland;Skare, Stefan;Glover, Gary H
通讯作者：
Glover, Gary H
影响因子：
4.4
作者：
Brück, W;Kuhlmann, T;Stadelmann, C
通讯作者：
Stadelmann, C
影响因子：
4.4
作者：
Gass, A;Niendorf, T;Hirsch, JG
通讯作者：
Hirsch, JG