A computational method for longitudinal mapping of orientation-specific expansion of cortical surface in infants.
A computational method for longitudinal mapping of orientation-specific expansion of cortical surface in infants.
复制标题
婴儿皮层表面定向扩张纵向映射的计算方法
DOI：
10.1016/j.media.2018.07.006
复制
发表时间：
2018-10
影响因子：
10.9
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Xia J;Wang F;Meng Y;Wu Z;Wang L;Lin W;Zhang C;Shen D;Li G
在出生后的第一年，人类大脑皮层表面的动态扩展和区域异质性。由于所有初级和次级皮质褶皱以及许多第三系皮质褶皱在足月出生时已经发育成熟，这一阶段皮质表面积的扩张主要是由切面上两个正交方向的表面积增加所驱动的：1)平行于褶皱方向的扩张（即褶皱长度的增加）和2)垂直于褶皱方向的扩张（即褶皱深度的增加）。这些信息将有助于我们更好地理解皮层发育的机制，并为神经发育障碍提供重要的见解，但由于缺乏专门的计算方法，这些信息在很大程度上仍然未知。为了解决这个问题，我们提出了一种新的方法来纵向绘制在婴儿期早期这两个正交方向的皮层表面积的定向特异性扩张。首先，为了得到垂直和平行于皮质褶皱的两个方向场，我们提出利用区域特异性可靠性，自适应平滑融合沟深梯度场和最大主方向场。具体来说，我们将此任务表述为一个离散标记问题，其中每个顶点被分配到一个方向标签，并通过图切来解决它。然后，基于计算得到的皮质表面纵向变形，通过求解最小二乘问题估计每个顶点处的雅可比矩阵，并推导出其对应的拉伸张量。最后，我们将拉伸张量分别投射到两个正交的方向上，以获得定向的皮质表面扩张。我们已将该方法应用于30名健康婴儿，并首次揭示了出生后一年内定向特异性纵向皮质表面扩张图。
The cortical surface of the human brain expands dynamically and regionally heterogeneously during the first postnatal year. As all primary and secondary cortical folds as well as many tertiary cortical folds are well established at term birth, the cortical surface area expansion during this stage is largely driven by the increase of surface area in two orthogonal orientations in the tangent plane: 1) the expansion parallel to the folding orientation (i.e., increasing the lengths of folds) and 2) the expansion perpendicular to the folding orientation (i.e., increasing the depths of folds). This information would help us better understand the mechanisms of cortical development and provide important insights into neurodevelopmental disorders, but still remains largely unknown due to lack of dedicated computational methods. To address this issue, we propose a novel method for longitudinal mapping of orientation-specific expansion of cortical surface area in these two orthogonal orientations during early infancy. First, to derive the two orientation fields perpendicular and parallel to cortical folds, we propose to adaptively and smoothly fuse the gradient field of sulcal depth and also the maximum principal direction field, by leveraging their region-specific reliability. Specifically, we formulate this task as a discrete labeling problem, in which each vertex is assigned to an orientation label, and solve it by graph cuts. Then, based on the computed longitudinal deformation of the cortical surface, we estimate the Jacobian matrix at each vertex by solving a least-squares problem and derive its corresponding stretch tensor. Finally, to obtain the orientation-specific cortical surface expansion, we project the stretch tensor into the two orthogonal orientations separately. We have applied the proposed method to 30 healthy infants, and for the first time we revealed the orientation-specific longitudinal cortical surface expansion maps during the first postnatal year.
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影响因子：
5.7
作者：
Kim H;Lepage C;Maheshwary R;Jeon S;Evans AC;Hess CP;Barkovich AJ;Xu D
通讯作者：
Xu D
影响因子：
11.2
作者：
CHI, JG;DOOLING, EC;GILLES, FH
通讯作者：
GILLES, FH
影响因子：
5.7
作者：
Li G;Nie J;Wang L;Shi F;Gilmore JH;Lin W;Shen D
通讯作者：
Shen D
DOI：
10.1523/jneurosci.4682-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
通讯作者：
Van Essen D
影响因子：
4.8
作者：
Meng Y;Li G;Rekik I;Zhang H;Gao Y;Lin W;Shen D
通讯作者：
Shen D