Regulation and control of myosin-I by the motor and light chain-binding domains.
Regulation and control of myosin-I by the motor and light chain-binding domains.
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DOI:
10.1016/j.tcb.2012.10.008
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发表时间:
2013-02
影响因子:
19
通讯作者:
Ostap EM
中科院分区:
文献类型:
--
作者:
Greenberg MJ;Ostap EM
Members of the myosin-I family of molecular motors are expressed in many eukaryotes where they are involved in a multitude of critical processes. Humans express 8 distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain binding domains of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and light chain binding domains.
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