Crossover-Use of Human Antibiotics in Livestock in Agricultural Communities: A Qualitative Cross-Country Comparison between Uganda, Tanzania and India.
Crossover-Use of Human Antibiotics in Livestock in Agricultural Communities: A Qualitative Cross-Country Comparison between Uganda, Tanzania and India.
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农业社区牲畜中人类抗生素的交叉使用：乌干达，坦桑尼亚和印度之间的定性越野比较。
DOI：
10.3390/antibiotics11101342
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发表时间：
2022-09-30
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
动物农业中抗生素的使用对全球抗生素的使用做出了重大贡献，是抗生素耐药性威胁不断上升的关键驱动因素。在低收入和中等收入国家，更好地了解抗生素在牲畜中的使用变得越来越重要，在这些国家，由于对动物源性产品的需求不断增长，抗生素的使用预计将大幅增加。抗生素交叉使用是指在动物身上使用获得许可的人类使用的抗生素制剂，反之亦然。这种做法有可能导致药物不良反应，并导致抗生素耐药性在人与动物之间的发展和传播。我们对深入访谈和焦点小组讨论记录进行了二次数据分析，这些记录来自调查乌干达、坦桑尼亚和印度农业社区抗生素使用的独立研究，以了解这些环境下药品提供者和牲畜饲养者交叉使用抗生素的做法。进行了专题分析，以探索这三个国家报告的抗生素交叉使用的驱动因素。在抗生素交叉使用的描述及其驱动因素方面，各国之间都发现了相似之处。在这三个国家，鸡和山羊都用人类抗生素治疗，在报告的所有人类抗生素范围中，阿莫西林、四环素和青霉素都被列为在所有三个国家的动物中使用。被确定为推动交叉使用的关键主题是：(1)药品提供者和牲畜饲养者对抗生素的有效性和安全性的看法，(2)牲畜饲养者的信息来源，(3)人类和兽医服务和抗生素的可获得性的差异，(4)经济激励和压力。抗生素的交叉使用发生在地理上不同的低收入和中等收入国家的低强度生产农业环境中，受到一组类似的相互关联的背景驱动因素的影响。除了采取干预措施解决人类和动物抗生素之间的差异以及交叉使用抗生素的潜在危险外，还需要提高牲畜饲养者和药品提供者对兽药的可及性和可负担性，以减少这种做法。为了理解一个部门的抗生素可及性和使用对其他部门的抗生素使用的影响，有必要采用统一健康的方法来研究抗生素的使用。
Antibiotic use in animal agriculture contributes significantly to antibiotic use globally and is a key driver of the rising threat of antibiotic resistance. It is becoming increasingly important to better understand antibiotic use in livestock in low-and-middle income countries where antibiotic use is predicted to increase considerably as a consequence of the growing demand for animal-derived products. Antibiotic crossover-use refers to the practice of using antibiotic formulations licensed for humans in animals and vice versa. This practice has the potential to cause adverse drug reactions and contribute to the development and spread of antibiotic resistance between humans and animals. We performed secondary data analysis of in-depth interview and focus-group discussion transcripts from independent studies investigating antibiotic use in agricultural communities in Uganda, Tanzania and India to understand the practice of antibiotic crossover-use by medicine-providers and livestock-keepers in these settings. Thematic analysis was conducted to explore driving factors of reported antibiotic crossover-use in the three countries. Similarities were found between countries regarding both the accounts of antibiotic crossover-use and its drivers. In all three countries, chickens and goats were treated with human antibiotics, and among the total range of human antibiotics reported, amoxicillin, tetracycline and penicillin were stated as used in animals in all three countries. The key themes identified to be driving crossover-use were: (1) medicine-providers’ and livestock-keepers’ perceptions of the effectiveness and safety of antibiotics, (2) livestock-keepers’ sources of information, (3) differences in availability of human and veterinary services and antibiotics, (4) economic incentives and pressures. Antibiotic crossover-use occurs in low-intensity production agricultural settings in geographically distinct low-and-middle income countries, influenced by a similar set of interconnected contextual drivers. Improving accessibility and affordability of veterinary medicines to both livestock-keepers and medicine-providers is required alongside interventions to address understanding of the differences between human and animal antibiotics, and potential dangers of antibiotic crossover-use in order to reduce the practice. A One Health approach to studying antibiotic use is necessary to understand the implications of antibiotic accessibility and use in one sector upon antibiotic use in other sectors.
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影响因子：
168.9
作者：
Holmes, Alison H.;Moore, Luke S. P.;Piddock, Laura J. V.
通讯作者：
Piddock, Laura J. V.
DOI：
10.1016/j.socscimed.2021.113813
发表时间：
2021-04
期刊：
Social science & medicine (1982)
影响因子：
--
作者：
Gautham M;Spicer N;Chatterjee S;Goodman C
通讯作者：
Goodman C
DOI：
10.3390/antibiotics10121433
发表时间：
2021-11-23
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
--
作者：
Arnold JC;Day D;Hennessey M;Alarcon P;Gautham M;Samanta I;Mateus A
通讯作者：
Mateus A
影响因子：
3.2
作者：
Gemeda, Biruk Alemu;Amenu, Kebede;Wieland, Barbara
通讯作者：
Wieland, Barbara
DOI：
10.1016/s2214-109x(21)00024-3
发表时间：
2021-05
期刊：
The Lancet. Global health
影响因子：
--
作者：
Do NTT;Vu HTL;Nguyen CTK;Punpuing S;Khan WA;Gyapong M;Asante KP;Munguambe K;Gómez-Olivé FX;John-Langba J;Tran TK;Sunpuwan M;Sevene E;Nguyen HH;Ho PD;Matin MA;Ahmed S;Karim MM;Cambaco O;Afari-Asiedu S;Boamah-Kaali E;Abdulai MA;Williams J;Asiamah S;Amankwah G;Agyekum MP;Wagner F;Ariana P;Sigauque B;Tollman S;van Doorn HR;Sankoh O;Kinsman J;Wertheim HFL
通讯作者：
Wertheim HFL