Cognitive correlates of dual tasking costs on the timed up and go test in Parkinson disease.
Cognitive correlates of dual tasking costs on the timed up and go test in Parkinson disease.
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DOI：
10.1016/j.prdoa.2022.100158
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kotagal, Vikas
中科院分区：
文献类型：
--
作者：
Harrie, Ashley;Hampstead, Benjamin M.;Lewis, Cate;Herreshoff, Emily;Kotagal, Vikas
不同的PD TUG双任务损伤具有不同的认知相关性。PD视觉空间缺陷与坐下时的双重任务问题相关。PD双任务跌倒风险可能不仅仅是由执行功能障碍引起的。双重任务损伤是帕金森病（PD）中福尔斯的一个越来越被认可的因素，可能是PD跌倒预防试验的一个有前途的治疗靶点。根据具体情况，不同类型的神经认知障碍可能会导致行走性双重任务处理困难。我们对21名PD参与者进行了横断面分析。所有参与者都接受了详细的神经心理学测试，使用规范的z分数进行量化。所有参与者都完成了3米计时和去测试（TUG），有和没有双重任务分配。使用APDM可穿戴OPAL传感器量化TUG的生物力学特性。我们探讨了双任务成本（DTC）在1）总TUG持续时间，2）坐到站的持续时间，3）站到坐的持续时间，和4）转身速度之间的相关性。TUG中受损的总DTC与使用蒙特利尔认知评估（莫卡）测量的整体认知表现呈负相关（r =-0.4649，p = 0.0337）。从坐到站的DTC损伤与WAIS-IV编码的处理速度（r =-0.5762，p = 0.0063）、语义流畅性（r =-0.5100，p = 0.0182）以及霍普金斯言语学习测试修订版总回忆的学习和记忆（r =-0.5502，p = 0.0098）呈负相关。在本顿判断线方向（JOLO）测试中，站到坐DTC功能受损与视觉空间认知功能呈负相关（r =-0.5181，p = 0.0161）。双重任务与PD跌倒风险之间的联系可能是由执行功能障碍以外的认知特征引起的，并且可能基于所讨论的走动任务而变化。这些发现阐明了认知对PD患者福尔斯跌倒的影响。
Different PD TUG dual tasking impairments have different cognitive correlates. PD visuospatial deficits correlate with dual tasking problems when sitting down. PD dual tasking fall risk may be caused by more than just executive dysfunction. Dual tasking impairments are an increasingly recognized contributor to falls in Parkinson disease (PD) and may be a promising therapeutic target for PD fall prevention trials. Depending on the context, ambulatory dual tasking difficulties may be caused by different types of neurocognitive impairments. We performed a cross-sectional analysis of 21 participants with PD. All participants underwent detailed neuropsychological testing that was quantified using normative z-scores. All participants completed the 3-meter timed up and go test (TUG), with and without a dual tasking assignment. Biomechanistic properties of the TUG were quantified using APDM wearable OPAL sensors. We explored correlations between dual tasking cost (DTC) in 1) total TUG duration, 2) Sit-to-stand duration, 3) Stand-to-sit duration, and 4) turn velocity. Impaired total DTC in the TUG correlated inversely with global cognitive performance measured using the Montreal Cognitive Assessment (MoCA) (r = −0.4649, p = 0.0337). Sit-to-stand DTC impairments correlated inversely with processing speed on the WAIS-IV Coding (r = −0.5762, p = 0.0063), semantic fluency (r = −0.5100, p = 0.0182) and learning and memory on the Hopkins Verbal Learning Test-Revised total recall (r = −0.5502, p = 0.0098). Impaired stand-to-sit DTC function corelated inversely with visuospatial cognitive function on the Benton Judgement of Line Orientation (JOLO) test (r = −0.5181, p = 0.0161). The link between dual tasking and fall risk in PD may be caused by cognitive features other than executive dysfunction and may vary based on the ambulatory task in question. These findings shed light on the cognitive contributions to falls in PD.
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