Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD.
Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD.
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DOI：
10.1016/j.rmed.2010.02.023
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发表时间：
2010-08
影响因子：
4.3
通讯作者：
Washko, George R.
中科院分区：
文献类型：
--
作者：
Diaz, Alejandro A.;Bartholmai, Brian;Estepar, Raul San Jose;Ross, James;Matsuoka, Shin;Yamashiro, Tsuneo;Hatabu, Hiroto;Reilly, John J.;Silverman, Edwin K.;Washko, George R.
目的：探讨慢性阻塞性肺疾病(COPD)患者肺气肿和呼吸道疾病与运动耐量的关系。我们研究了93名在肺组织研究协会登记的慢性阻塞性肺疾病患者(1 S用力呼气量[FEV1]%预测值±SD57.1±24.3%，女性=40例)。肺气肿定义为CT扫描上低于−950Hounsfield单位(%LAA950)阈值的低密度区域的百分比。对第3~6代右上叶尖支气管壁面积百分比(Wa%)进行分析。6分钟步行距离(6MWD)测试被用作运动能力的衡量标准。6MWD与%LAA950呈负相关(r=−0.53，p&t；0.0001)，与第6代−的Wa%呈负相关(r=0.28，p=0.009)。在包括肺气肿和呼吸道疾病的CT指数的多元回归模型中，根据人口统计学和生理变量以及CT扫描仪的品牌进行调整，只有%LAA-950仍然与运动能力显著相关。在其他协变量不变的情况下，该模型显示CT肺气肿每增加10%，步行距离减少6分钟2 8.6米(95%可信区间=−5 1.2，−6.0，p=0.0 1)。这些结果表明，容量CT测量的肺气肿程度而不是呼吸道疾病的程度独立地影响了COPD受试者的运动限制。
To assess the association of emphysema and airway disease assessed by volumetric computed tomography (CT) with exercise capacity in subjects with chronic obstructive pulmonary disease (COPD). We studied 93 subjects with COPD (Forced Expiratory Volume in 1 s [FEV1] %predicted mean ± SD 57.1 ± 24.3%, female gender = 40) enrolled in the Lung Tissue Research Consortium. Emphysema was defined as percentage of low attenuation areas less than a threshold of −950 Hounsfield units (%LAA-950) on CT scan. The wall area percentage (WA%) of the 3rd to 6th generations of the apical bronchus of right upper lobe (RB1) were analyzed. The six-minute walk distance (6MWD) test was used as a measure of exercise capacity. The 6MWD was inversely associated with %LAA-950 (r = −0.53, p<0.0001) and with the WA% of 6th generation of RB1 only (r = −0.28, p = 0.009). In a multivariate regression model including CT indices of emphysema and airway disease that were adjusted for demographic and physiologic variables as well as brand of CT scanner, only the %LAA-950 remained significantly associated with exercise performance. Holding other covariates fixed, this model showed that a 10% increase of CT emphysema reduced the distance walked in six minutes 28.6 meters (95% Confidence Interval = −51.2, −6.0, p = 0.01). These results suggest that the extent of emphysema but not airway disease measured by volumetric CT contributes independently to exercise limitation in subjects with COPD.
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影响因子：
24.3
作者：
Cote, C. G.;Casanova, C.;Celli, B. R.
通讯作者：
Celli, B. R.
DOI：
10.1164/ajrccm.163.6.2003172
发表时间：
2001-05-01
影响因子：
24.7
作者：
Marin, JM;Carrizo, SJ;Celli, BR
通讯作者：
Celli, BR
DOI：
10.1164/ajrccm.162.3.9907120
发表时间：
2000-09-01
影响因子：
24.7
作者：
Nakano, Y;Muro, S;Mishima, M
通讯作者：
Mishima, M
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
--
影响因子：
4.8
作者：
Matsuoka, Shin;Washko, George R.;Dransfield, Mark T.;Yamashiro, Tsuneo;Estepar, Raul San Jose;Diaz, Alejandro;Silverman, Edwin K.;Patz, Samuel;Hatabu, Hiroto
通讯作者：
Hatabu, Hiroto