Learned together, extinguished apart: reducing fear to complex stimuli.
Learned together, extinguished apart: reducing fear to complex stimuli.
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DOI：
10.1101/lm.031740.113
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发表时间：
2013-11-15
期刊：
影响因子：
--
通讯作者：
Monfils MH
中科院分区：
文献类型：
--
作者：
Jones CE;Ringuet S;Monfils MH
将先前中性的条件刺激（CS;例如，音调）到厌恶的无条件刺激（US;例如，脚电击）导致联想学习，使得音调单独引起条件反应（例如，冷冻）。我们以前已经表明，灭绝会议内发生的再巩固窗口衰减恐惧反应，并防止返回的恐惧在纯音巴甫洛夫恐惧条件反射。在这里，我们试图检验这种效应是否也适用于更复杂的恐惧记忆。首先，我们表明，恐惧条件反射后，同时提出的音调和光（T+L）coterminating与休克，复合记忆，england是更耐恐惧灭绝比简单的色调休克配对。接下来，我们证明了复合记忆可以被中断的两个单独的组件使用顺序检索+灭绝范式的重新整合，提供了更强的复合组件首先检索。这些发现提供了对复合记忆如何编码的深入了解，并可能对PTSD治疗产生重要影响。
Pairing a previously neutral conditioned stimulus (CS; e.g., a tone) to an aversive unconditioned stimulus (US; e.g., a footshock) leads to associative learning such that the tone alone comes to elicit a conditioned response (e.g., freezing). We have previously shown that an extinction session that occurs within the reconsolidation window attenuates fear responding and prevents the return of fear in pure tone Pavlovian fear conditioning. Here we sought to examine whether this effect also applies to a more complex fear memory. First, we show that after fear conditioning to the simultaneous presentation of a tone and a light (T+L) coterminating with a shock, the compound memory that ensues is more resistant to fear extinction than simple tone-shock pairings. Next, we demonstrate that the compound memory can be disrupted by interrupting the reconsolidation of the two individual components using a sequential retrieval+extinction paradigm, provided the stronger compound component is retrieved first. These findings provide insight into how compound memories are encoded, and could have important implications for PTSD treatment.
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影响因子：
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DOI：
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发表时间：
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期刊：
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发表时间：
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期刊：
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