Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.
Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.
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DOI：
10.1002/ana.22015
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发表时间：
2010-10
影响因子：
11.2
通讯作者：
Trojanowski, John Q.
中科院分区：
文献类型：
--
作者：
Hamilton, Roy;Patel, Sunil;Lee, Edward B.;Jackson, Eric M.;Lopinto, Joanna;Arnold, Steven E.;Clark, Christopher M.;Basil, Anuj;Shaw, Leslie M.;Xie, Sharon X.;Grady, M. Sean;Trojanowski, John Q.
为了确定皮质性阿尔茨海默病病理对特发性正常压力脑积水（iNPH）患者分流反应性的影响，37名临床诊断为iNPH的患者参加了一项前瞻性研究，在该研究中，分流术前和4个月后的神经学、心理测量和步态测量的表现与分流术插入期间皮质活检中观察到的β淀粉样斑块、神经炎斑块和神经原纤维缠结相关。活检采集无并发症。与没有病理的患者相比，中度至重度病理患者的基线认知能力较差，术后在NPH症状严重程度量表、步态测量和认知工具上的改善减弱。
To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid β plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology.
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影响因子：
11
作者：
Bech-Azeddine, R.;Hogh, P.;Waldemar, G.
通讯作者：
Waldemar, G.
影响因子：
11
作者：
Golomb, J;Wisoff, J;Graves, W
通讯作者：
Graves, W
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
DOI：
10.1097/00005072-199904000-00008
发表时间：
1999-04-01
影响因子：
3.2
作者：
Davis, DG;Schmitt, FA;Markesbery, WR
通讯作者：
Markesbery, WR
影响因子：
4.5
作者：
McBride, T;Moberg, PJ;Gur, RE
通讯作者：
Gur, RE