Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
复制标题
核糖体蛋白S12E在细胞竞争中具有独特的功能。
DOI：
10.1016/j.devcel.2017.12.007
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发表时间：
2018-01-08
影响因子：
11.8
通讯作者：
Baker NE
中科院分区：
文献类型：
--
作者：
Kale A;Ji Z;Kiparaki M;Blanco J;Rimesso G;Flibotte S;Baker NE
野生型果蝇细胞可以从遗传嵌合体中去除核糖体蛋白突变杂合的细胞（称为“微小”突变细胞），这一过程称为细胞竞争。核糖体蛋白S12是不寻常的，因为rpS12突变的杂合细胞不与野生型竞争，并且rpS12中的可行错义突变保护Minute细胞免受与野生型细胞的细胞竞争。此外，通过改变rpS12的基因剂量，诱导具有微小突变的细胞相互竞争，消除具有比其邻居更多的rpS12的细胞。因此，RpS12在细胞竞争中具有特殊的功能，其定义了细胞的竞争力。我们提出，野生型和微小细胞之间的细胞竞争是由RpS12介导的核糖体蛋白单倍不足的信号启动的。由于表达不同水平Myc的细胞之间的竞争不需要RpS12，因此其他类型的细胞竞争可能以不同的方式启动。核糖体蛋白基因突变的细胞通过细胞竞争从果蝇组织中被淘汰，但是突变是如何被检测出来的呢？Kale等人表明核糖体蛋白S12是细胞竞争所必需的。这项研究表明，S12具有独特的信号功能，靶向细胞进行竞争。
Wild-type Drosophila cells can remove cells heterozygous for ribosomal protein mutations (known as “Minute” mutant cells) from genetic mosaics, a process termed cell competition. The ribosomal protein S12 was unusual because cells heterozygous for rpS12 mutations were not competed by wild-type, and a viable missense mutation in rpS12 protected Minute cells from cell competition with wild-type cells. Furthermore, cells with Minute mutations were induced to compete with one another by altering the gene dose of rpS12, eliminating cells with more rpS12 than their neighbors. Thus RpS12 has a special function in cell competition that defines the competitiveness of cells. We propose that cell competition between wild-type and Minute cells is initiated by a signal of ribosomal protein haploinsufficiency mediated by RpS12. Since competition between cells expressing different levels of Myc did not require RpS12, other kinds of cell competition may be initiated differently. Cells with mutations in ribosomal protein genes are eliminated from Drosophila tissues by cell competition, but how are mutations detected? Kale et al. show that ribosomal protein S12 is necessary for cell competition. The study suggests that S12 has a distinct signaling function that targets cells for competition.
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